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Prädiktoren der linksatrialen Thromben und Spontanechokontrastierung bei Patienten mit Vorhofflimmern vor geplanter Kardioversion – Eine monozentrische Erfahrung – eine systematische Analyse

dc.contributor.advisorTebbe, Ulrich Prof. Dr.
dc.contributor.authorBejinariu, Alexandru Gabriel
dc.date.accessioned2018-01-08T09:47:58Z
dc.date.available2018-02-13T23:50:46Z
dc.date.issued2018-01-08
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-002E-E314-0
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-6665
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titlePrädiktoren der linksatrialen Thromben und Spontanechokontrastierung bei Patienten mit Vorhofflimmern vor geplanter Kardioversion – Eine monozentrische Erfahrung – eine systematische Analysede
dc.typecumulativeThesisde
dc.title.translatedPredictors for left atrial thrombi and spontaneous echo contrast in patients with atrial fibrillation before planed cardioversion - A monocentric experience - A systematic analysisde
dc.contributor.refereeLotz, Joachim Prof. Dr.
dc.date.examination2018-02-06
dc.description.abstractengBackground. It is known that atrial fibrillation is associated with a higher risk for embolic events. Left atrial appendage thombi and spontaneous echocardiographic contrast (SEC) are known to positively correlate with this risk. We studied the laboratory, echocardiographic and epidemiologic parameters that could predict the left atrial thrombi and the intensity of the SEC. Methods. Between September 2013 and June 2015 we included a total of 372 patients with atrial fibrillation before planned electrical cardioversion (transesophageal guided strategy). After assessing the stroke and bleeding risks (CHA2DS2-VASc and HAS-BLED scores), we measured the concentration of the D-Dimer and B-type natriuretic peptide at the time of the transesophageal echocardiography and the left atrial volume and the ejection fraction in a transthoracic echocardiography. Results. The ejection fraction and the CHA2DS2-VASc score were identified as independent predictors of both left atrial thrombi and SEC, whereas the left atrial volume could only predict the intensity of SEC. In contrast to other studies, the studied biomarkers failed to predict the outcome. Conclusion. Only the echocardiographic and epidemiologic parameters were predictors of left atrial thrombi and SEC intensity, the studied biomarkers had no predictive power. Using clinical data and transthoracic echocardiography we can further stratify the thromboembolic risk in uncertain cases.de
dc.contributor.coRefereeOppermann, Martin Prof. Dr.
dc.subject.engthrombusde
dc.subject.engatrial fibrillationde
dc.subject.engleft atriumde
dc.subject.engtransoesophageal echocardiographyde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-002E-E314-0-5
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullInnere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747)de
dc.description.embargoed2018-02-13
dc.identifier.ppn1010385232


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