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Etablierung und Charakterisierung eines experimentellen Modells für invasive Gliome

dc.contributor.advisorLudwig, Hans-Christoph Prof. Dr.
dc.contributor.authorRichter, Christoph
dc.date.accessioned2018-04-04T08:25:26Z
dc.date.available2018-04-12T22:50:06Z
dc.date.issued2018-04-04
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-002E-E3AA-D
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-6819
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titleEtablierung und Charakterisierung eines experimentellen Modells für invasive Gliomede
dc.typedoctoralThesisde
dc.title.translatedEstablishment and characterization of an experimental model for invasive gliomasde
dc.contributor.refereeLudwig, Hans-Christoph Prof. Dr.
dc.date.examination2018-04-05
dc.description.abstractengGliomas belong to the most malignant cancers we know. It is accepted that origin of the disease and glioma progression is caused by glioma-initiating cells (GICs). These cells have stem-cell attributes and are thought to provide target for new therapeutic options. GIC`s still lack of reliable markers to be identified in the heterogenous Tumors. This study examines glioma cell line G112 in vitro and in vivo. Stem-cell attributes are investigated in vitro. A very invasive phenotype and radioresistance have been verified in an orthotopic model. A reliable model for invasive gliomas has been established and has been characterized for the first time.de
dc.contributor.coRefereeKramm, Christof Prof. Dr.
dc.subject.gerGlioblastomde
dc.subject.engGliomade
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-002E-E3AA-D-8
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.subject.gokfullNeurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)de
dc.description.embargoed2018-04-12
dc.identifier.ppn1017793034


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