Charakterisierung des Targetingverhaltens präsynaptischer Proteine

Charakterisierung des Targetingverhaltens präsynaptischer Proteine

Characterization of the targeting of presynaptic proteins

Donatus Riemann

Doctoral thesis

Date of Examination: 2018-05-14

Date of issue: 2018-04-24

Advisor: Dresbach, Thomas Prof. Dr.

Referee: Rizzoli, Silvio Prof. Dr.

Referee: Mausberg, Rainer Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-002E-E3C6-D

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Abstract

English

Studying features of proteins can be done by expressing recombinant versions of those proteins in a cellular environment which facilitates correct transport and distribution. Here this model was used to study features of recombinant versions of Bassoon, a structural component of active zones, RIBEYE, a protein involved in building ribbon synapses and Rogdi, a protein that had never been described in synapses before.

Keywords: Rogdi, Bassoon, RIBEYE; Mover; Neuron; Synapse; Hippocampus; Transfection; Recombinant