Synthesis of Rigid Spin Labels for the Investigation of Transmembrane Peptides by EPR Spectroscopy

Wegner, Janine

dc.contributor.advisor	Diederichsen, Ulf Prof. Dr.
dc.contributor.author	Wegner, Janine
dc.date.accessioned	2018-04-27T09:04:13Z
dc.date.available	2018-04-27T09:04:13Z
dc.date.issued	2018-04-27
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002E-E3CF-C
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6854
dc.language.iso	eng	de
dc.publisher	Niedersächsische Staats- und Universitätsbibliothek Göttingen	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	540	de
dc.title	Synthesis of Rigid Spin Labels for the Investigation of Transmembrane Peptides by EPR Spectroscopy	de
dc.type	doctoralThesis	de
dc.contributor.referee	Diederichsen, Ulf Prof. Dr.
dc.date.examination	2018-02-28
dc.description.abstracteng	Transmembrane model peptides enable the investigation of complex protein-lipid interactions since the specific structure of proteins is influenced by the lipid environment. Herein, the synthesis of nitroxide spin labels for transmembrane peptides is present and PEDLOR nanometer distance measurements are discussed. It was demonstrated that the combination of semi-rigid labels with high-power pulsed EPR allows straightforward structural interpretation of the observed distances in solution and lipid bilayer. In particular, the labels deliver reliable distances and sharp distance distributions even in the lipid bilayer.	de
dc.contributor.coReferee	Bennati, Marina Prof. Dr.
dc.subject.eng	nitroxide radical	de
dc.subject.eng	spin label	de
dc.subject.eng	transmembrane peptides	de
dc.subject.eng	EPR	de
dc.subject.eng	PELDOR	de
dc.subject.eng	membrane	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E3CF-C-2
dc.affiliation.institute	Fakultät für Chemie	de
dc.subject.gokfull	Chemie (PPN62138352X)	de
dc.identifier.ppn	1022271830

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Fakultät für Chemie (inkl. GAUSS) [701]

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