| dc.contributor.advisor | Göpfert, Martin Prof. Dr. | |
| dc.contributor.author | Katana, Radoslaw | |
| dc.date.accessioned | 2019-02-13T08:58:09Z | |
| dc.date.available | 2019-02-13T08:58:09Z | |
| dc.date.issued | 2019-02-13 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-002E-E591-4 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-7283 | |
| dc.language.iso | eng | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 570 | de |
| dc.title | Chromophore-independent roles of Drosophila opsin apoproteins and visual cycle components | de |
| dc.type | doctoralThesis | de |
| dc.contributor.referee | Göpfert, Martin Prof. Dr. | |
| dc.date.examination | 2018-11-23 | |
| dc.description.abstracteng | Visual rhodopsins consist of opsin protein moieties that are covalently bound to 11-cis-retinal, the visual chromophore that is derived from vitamin A. In Drosophila, the visual opsin genes Rh5 and Rh6 were reported to be expressed also in auditory sensory cells, contributing to mechanical amplification in hearing and sound transduction. In my thesis I report that these opsin functions are visual chromophore in-dependent. No auditory phenotypes ensued when flies were raised on vitamin-A depleted medium, and disrupting genes implicated in the de novo synthesis of 11-cis-retinal from vitamin A, i.e. ninaB and ninaD, likewise left hearing un-affected. Genes implicated in the re-cycling of 11-cis-retinal, i.e. pinta, ninaG, rdhB, and pdh, however, all turned out to be required for hearing, indicating that although the visual chromophore is dispensable for hearing, Drosophila auditory sensory cells might share the genetic pathway that, in Drosophila photoreceptors, mediates visual chromophore recycling. | de |
| dc.contributor.coReferee | Fiala, André Prof. Dr. | |
| dc.contributor.thirdReferee | Schmidt, Manuela Dr. | |
| dc.contributor.thirdReferee | Vorbrüggen, Gerd Dr. | |
| dc.contributor.thirdReferee | Großhans, Jörg Prof. Dr. | |
| dc.contributor.thirdReferee | Clemens, Jan Dr. | |
| dc.subject.eng | Chromophore | de |
| dc.subject.eng | Opsin | de |
| dc.subject.eng | Drosophila hearing | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E591-4-5 | |
| dc.affiliation.institute | Biologische Fakultät für Biologie und Psychologie | de |
| dc.subject.gokfull | Biologie (PPN619462639) | de |
| dc.identifier.ppn | 1049083113 | |