Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Dobbelstein, Matthias Prof. Dr."
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Role of Distal Regulatory Elements in Cancer Progression and Therapy
(2019-01-11)Enhancer elements comprise of regions of DNA that are distal to gene promoters with a characteristic capacity to affect and regulate gene transcription. Enhancers are enriched in a highly context-specific manner allowing ... -
Role of endogenous retrovirus promoter activity in tumor suppression
(2015-06-03)Roughly 8% of the human genome consists of human endogenous retroviruses (HERVs). They are believed to be remnants of ancient retroviral infections of the germline that were passed on from one generation to the next over ... -
Role of the Hedgehog receptor Patched1 in the development and function of T lymphocytes
(2013-06-18)The hedgehog signalling pathway is a highly conserved key regulator of animal development and required for homeostasis of adult tissues both in invertebrates and vertebrates. In addition, a large number of studies have ... -
The accumulation of mutant p53 in human cancer cells
(2011-07-04)The tumor suppressor p53 is mutated in more than 50% of all human solid tumors. This comprises mostly single residue missense point mutations that entail a loss of p53 tumor suppressor ... -
The impact of the integrated stress response on DNA replication
(2020-05-27)The integrated stress response (ISR) is activated following various stress stimuli which leads to the phosphorylation of the translation initiation factor eIF2alpha. Phosphorylation of eIF2alpha blocks cap−dependent ... -
The membrane IgE tail imparts unique signaling properties to the B cell antigen receptor
(2017-10-23)Robust memory antibody responses are a distinguishing feature of humoral immunity and are typically marked by elevated serum immunoglobulin (Ig) titers that rapidly and effectively neutralize the invading pathogen. However, ... -
The p53 homolog p73 takes hold of the male germ line – a novel function of TAp73 in protecting sperm cell adhesion, migration and maturation within the seminiferous epithelium of the testis
(2013-11-19)The p53 family of transcription factors possesses diverge functions in tumorigenesis and development. The evolutionarily conserved role of the family member p63 to protect the genetic stability of germ cells and influence ... -
The Role of ARID1A in Oncogenic Transcriptional (de)Regulation in Colorectal Cancer
(2019-07-23)The deregulation of epigenetic modulation has been well established as a common occurrence in cancer. However, the extent of its involvement in the development and progression of cancer was underscored by genome- and ... -
The Role of BRDT in Esophageal Squamous Cell Carcinoma
(2021-01-08)Esophageal squamous cell carcinoma (ESCC), the predominant subtype of esophageal cancer, remains a deadly malignancy due to the lack of effective therapies. Precision oncology, utilizing various techniques to identify ... -
The role of microRNAs in the p53 tumor suppressor pathway
(2011-12-16)MicroRNAs (miRNAs) are a class of small, non-coding, double-stranded RNA molecules. In metazoan cells, miRNAs recognize their target mRNAs by imperfectly complementary binding, leading to ... -
The Role of RNF40 mediated H2B monoubiquitination in transcription
(2017-02-13)Active gene transcription is tightly correlated with the occupancy of histone H2B monoubiquitination (H2Bub1) in the transcribed region. Therefore, it is has been commonly assumed that H2Bub1 is an exclusively positively ... -
The Role of the Hedgehog Receptor Patched in LysM+ Cells in Mice
(2013-12-04)Cancer development is frequently linked to signaling pathways that are required for normal embryonic patterning. One of the pathways important in patterning and growth of the embryo is the Hedgehog (Hh) signaling cascade. ... -
Wif1 Inhibits the Growth of Basal Cell Carcinoma
(2015-12-22)Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin cancers and is the most commonly diagnosed cancer in fair-skinned individuals. In the majority of BCC the tumor suppressor gene patched1 (PTCH) is ...