Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Dresbach, Thomas Prof. Dr."
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Quantitative Multicolour Nanoscopy for the Investigation of the Postsynaptic Actin Cytoskeleton
(2023-08-16)Cognitive processes like the formation of memory and learning originate in the correct functioning of synapses. Dendritic spines are highly plastic, specialised actin-rich structures harbouring the postsynaptic site in ... -
Synergistic SNARE Modulators of Neurotransmission: Complexins and SNAP-29
(2016-05-04)Neurotransmitter release is a synergistic multistep process occurring at synapses in the brain. Synaptic vesicles containing neurotransmitters tether to the presynaptic active zones, upon which, they are docked and primed ... -
The influence of epigenetic alterations on synaptic function and memory
(2022-08-24)While memory formation is traditionally linked to changes in synaptic structure, the transcriptional processes enabling these changes are often understudied. Even though novel protein synthesis is the basis of long-term ... -
The presynaptic protein Mover is heterogeneously expressed across brain areas and synapse types
(2019-06-24)Synaptic nerve terminals are highly specialized sites where complex processes are taking place. The regulation of these complex processes is mediated by an intricate machinery of presynaptic proteins. While most of these ... -
The role of Calcium Binding Protein 2 in synaptic sound encoding and hearing
(2016-11-29)Hearing is a unique sensory feature providing the individual with acoustic information about the surrounding environment. Humans rely on hearing to localize potential dangers and it is essential for communication and social ... -
The role of N-truncated Aβ peptides in Alzheimer’s Disease
(2018-06-29)The N-terminally truncated pyroglutamate Aβ3−42 (AβpE3−42) and Aβ4−42 peptides are known to be highly abundant in the brain of Alzheimer’s disease (AD) patients. Both peptides show enhanced aggregation and neurotoxicity ... -
Ultrafast Multichannel Optogenetic Stimulation of the Auditory Pathway for Optical Cochlear Implants
(2019-01-14)In case of profound sensorineural hearing loss and deafness, cochlear implants (CIs) partially restore hearing and provide missing auditory information to the brain. Electrical stimulation of the spiral ganglion neurons ... -
Ultrastructural Characterization of The Output of VIP Expressing Interneurons in Mouse Barrel Cortex
(2017-11-15)Based on this preliminary result, a quantitative immunoelectron microscopy study was adopted to comprehensively characterize the output of VIP interneurons across the whole laminae of mouse barrel cortex. Using VIPcre/YFP ... -
Wiring and information processing in the olfactory bulb of larval Xenopus laevis
(2020-02-04)Olfactory systems of vertebrates have adapted to the various challenges of their environments on both the level of odorant receptors and neuronal wiring. Amphibians like the African clawed frog Xenopus laevis offer a ... -
α-synuclein disrupts neuron network rhythmic activity when overexpressed in cultured neurons
(2021-03-09)Synucleinopathies are associated with a generalized slowing of the brain’s rhythmic activity, which co-occurs with dementia and has been connected with increased levels of α synuclein in both patients and test animals. In ...