Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Heinrich, Ralf Prof. Dr."
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Morphological Studies of Synaptic Vesicle Recycling at the Inner Hair Cell Ribbon Synapse
(2020-01-10)Within the mammalian inner ear, sensory inner hair cells (IHCs) of the organ of Corti are required to transduce sound waves into electrical signals. Specialized synapses at the IHC basal pole, so-called ribbon synapses, ... -
Network formation and reorganization of the olfactory system of Xenopus laevis
(2022-03-03)The olfactory system is a window to the chemical world, that permits each species to adapt to novel spaces and situations. Despite the various phylogenetic adaptations, this sensory system maintains similar functional and ... -
Neue Behandlungsansätze für neuropsychiatrische Erkrankungen basierend auf der Identifizierung molekularer Krankheitsdeterminanten
(2009-04-21)Major neuropsychiatric diseases, including schizophrenia and bipolar disorder, deteriorate higher brain functions leading to disorganized thinking and cognitive decline. Available treatments ... -
Neural circuit plasticity underlying learning and memory in Drosophila melanogaster: from synaptic connections to behavior
(2023-05-12)Understanding the principles behind olfactory higher-order associative chains formation in Drosophila is one step further into unraveling the essence of learning and memory. However, the rationale behind such mechanisms ... -
Optical Analysis of Synaptic Plasticity Underlying Associative Learning in Drosophila melanogaster
(2018-10-10)Learning and memory is a prerequisite for the survival and the appropriate adaptation of behavioral responses in an ever-changing environment. Memories are formed, stored, and retrieved in the brains of animals. The formation ... -
Peripheral nervous system control for neuroprostheses
(2017-09-21)Amputee patients who have lost a hand or arm are severely impaired in their daily life, as they lose the ability to grasp and interact with their environment. While the use of electromyographically controlled prosthetic ... -
Probing roles of TRPML in Drosophila hearing
(2016-01-15)Several transient receptor potential (TRP) channels have been implicated in Drosophila hearing, including the TRPN channel NOMPC, the TRPVs Nan and Iav, and the TRPA members Pyx and Pain. Here I report that fly hearing ... -
Signalling of hematopoietic growth factors in mammalian neural cells
(2007-07-31)This dissertation examines signalling of hematopoietic growth factors in hippocampal neurons and cortical astrocytes. The activity patterns of Akt, ERK1/2 and Stat3 after treatment with ... -
Super-resolution of PSD95 remodelling during synaptic plasticity
(2021-07-01)Strengthening and weakening of synapses are a fundamental information processing unit within the neuronal circuit of the brain. It has been shown that the most abundant scaffold protein of the postsynaptic density (PSD), ... -
The influence of epigenetic alterations on synaptic function and memory
(2022-08-24)While memory formation is traditionally linked to changes in synaptic structure, the transcriptional processes enabling these changes are often understudied. Even though novel protein synthesis is the basis of long-term ... -
The role of oligodendrocytes in higher-order circuit functions
(2018-11-12)The historical conception of glial cells as the ‘glue’ that holds the brain together has dramatically changed in the last years. The glia plays an active role in several mechanisms related to information processing in the ... -
Therapeutic approaches for two distinct CNS pathologies
(2020-06-19)This work summarizes the analysis of two distinct therapeutic approaches for the central nervous system (CNS) pathologies, Pelizaeus-Merzbacher disease (PMD) and Glioblastoma multiforme (GBM). PMD is a severe leukodystrophy ... -
Ultrafast Multichannel Optogenetic Stimulation of the Auditory Pathway for Optical Cochlear Implants
(2019-01-14)In case of profound sensorineural hearing loss and deafness, cochlear implants (CIs) partially restore hearing and provide missing auditory information to the brain. Electrical stimulation of the spiral ganglion neurons ... -
Untangling neuronal diversity: a quantitative electrophysiological and morphological characterization of VIP expressing interneurons
(2017-03-21)VIP expressing interneurons are an essential component of cortical circuitry. This distinct subgroup of inhibitory interneurons was always described as the most heterogeneous subgroup of inhibitory interneurons. However, ... -
White matter integrity of the frontal brain and its relevance for catatonia and executive function
(2021-11-22)Catatonia is a CNS derived psychomotor syndrome comprising disturbed volition and aberrant motor and behavioral features. Targeted and effective treatment today is scarce and further impeded by its heterogeneous clinical ...