Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Rodnina, Marina Prof. Dr."
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Regulation of human 48S initiation complex formation
(2024-04-23)During the initiation phase of protein synthesis in humans, the small ribosome subunit interacts with initiator tRNA (tRNAi) and at least ten different initiation factors (eIFs) to form the initiation complex. The initiation ... -
Release of a Natural mRNA During Recycling of the Prokaryotic Ribosome
(2023-06-20)Ribosome recycling is the last step of the bacterial translation cycle. The release of the peptide leaves a 70S ribosome with a deacylated tRNA in the P site and the stop codon of the mRNA in the A site. The combined action ... -
Ribosome dynamics during spontaneous frameshifting
(2022-10-18)During protein synthesis, the ribosome moves along the mRNA in steps of three nucleotides at a time to maintain the translational reading frame. However, on some mRNA sequences that are denoted as slippery, ribosomes may ... -
Strategies to stabilize RNP complexes for structural determination by 3D cryo-electron microscopy
(2014-10-24)The physiological reactions in a cell are generally not performed by single biological macromolecules, but by complexes of several molecules. They can be a complex of several proteins or can be composed of RNA and proteins ... -
Structural and functional investigation of the protein synthesis in saccharomyces cerevisiae
(2012-02-24)Protein synthesis is an important house-keeping activity of all the cells. It follows the same concepts in all three domains of life: the genetic code is deciphered and transcribed into the ... -
Structural and functional studies of the spliceosomal RNP remodeling enzyme Brr2
(2013-06-25)The spliceosome is a highly dynamic, multi-MDa eukaryotic RNA-protein (RNP) machinery that catalyzes precursor messenger RNA (pre-mRNA) splicing. Pre-mRNA splicing entails the excision of non-coding introns and the joining ... -
Structural Characterization of the Eukaryotic Translation Initiation by Electron Cryo-Microscopy
(2019-05-08)Translation is a highly conserved molecular process during which the genetic information stored in an mRNA molecule is translated into a polypeptide chain that eventually folds into functional three-dimensional proteins. ... -
Structural Survey on Cohesin and Viomycin Inhibited 70S Ribosome by Single Particle Electron Microscopy
(2016-04-21)Life can be understood as the systematic collaborative action of several entities on molecular level reducing locally the entropy at the cost of the exterior environment. These entities are in great part macromolecular ... -
Structure and Mechanism of the Flavoenzyme Lipoamide Dehydrogenase from Escherichia coli
(2016-08-29)The flavoenzyme lipoamide dehydrogenase (E3) is an ubiquitously distributed enzyme which is part of several multienzyme complexes involved in cellular carbon metabolism thus contributing to cellular homeostasis. It catalyzes ... -
Structure-function analysis of human nucleotide excision DNA repair
(2021-04-09)An average human cell accumulates tens of thousands of DNA lesions per day. Therefore, DNA repair pathways are set up to continuously proofread the DNA and correct DNA lesions, thus ensuring accurate expression and ...