Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Wolf, Fred Prof. Dr."
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Numerical Simulations on the Biophysical Foundations of the Neuronal Extracellular Space
(2013-11-25)The electric activity of neurons creates extracellular potential fields. Recent findings show that these endogenous fields act back onto the neurons, contributing to synchronization of population activity. The influence ... -
On the Speed of Neuronal Populations
(2017-10-10)This thesis presents novel results in the areas of closed loop electrophysiology and neuronal population coding. This work begins by presenting the first known attempt to control the spike rate of a neuron or neurons using ... -
Optimization principles and constraints shaping visual cortical architecture
(2012-05-03)Neurons in the mammalian primary visual cortex (V1) are often preferentially driven by only one of the two eyes and respond best to oriented bar stimuli at a particular position in the visual field. Most carnivorans and ... -
Perturbation Growth and Prediction of Extreme Events
(2018-11-15)Extreme events occur in a variety of dynamical systems. Here we employ quantifiers of chaos to identify changes in the dynamical structure of complex systems preceding an extreme event. -
Physiological Classification of Retinal Ganglion Cells in the Salamander Retina
(2016-04-13)The retina is a complex neural network, responsible for breaking down the visual scene into its distinctive features such as local contrast, motion and color. The retinal ganglion cells form the output layer of this ... -
Processing of Graded Signaling Systems
(2016-03-24)Vocal repertoires of nonhuman animals and especially of terrestrial mammals are often characterized by their relatively small size of innate vocal types which can show considerable variation in acoustic structure. To ... -
Reading memory traces in cultured neuronal networks by probabilistic analysis
(2014-02-21)In this thesis, I am studying the enhancement of the collective burst dynamics, burst activation and propagation in hippocampal neuronal networks in-vitro by using optogenetic techniques. Channelrhodopsin-2 transfected ... -
Receptive field organization of motion computation in the fly: a study of cell types and their variability
(2020-12-02)It is believed that knowing all cell types making up a brain will lead to its understanding. Consequently, current efforts focus on classifying cell types according to their anatomical, genetic and physiological properties. ... -
Reverse-time inference of biological dynamics
(2020-10-27)In this work I derive a mathematical theory that allows to infer directional biological dynamics in reverse time starting from their target state. I use this approach to infer an effective model of cell junction shrinkage ... -
Role of mechanosensitive ion channels in coordinated epithelial cell dynamics in Drosophila
(2019-11-20)Epithelial cells are able to sense and mechanically respond to the forces and movements generated and transmitted through their neighbors. These forces are multicellular at the tissue level, and are transmitted via multimeric ... -
Sound Encoding in the Mouse Cochlea: Molecular Physiology and Optogenetic Stimulation
(2014-04-24)Afferent synapses between inner hair cells (IHCs) and spiral ganglion neurons in the cochlea translate sound information into a discrete spike code, providing us the opportunity to directly observe the output of the cochlea. ... -
Spatial, feature and temporal attentional mechanisms in visual motion processing
(2013-06-27)The three projects documented in this thesis investigated the role of three forms of attention in visual processing. Spatial, feature-based and temporal attention. The spatial and feature-based attentional characteristics ... -
Super-resolution of PSD95 remodelling during synaptic plasticity
(2021-07-01)Strengthening and weakening of synapses are a fundamental information processing unit within the neuronal circuit of the brain. It has been shown that the most abundant scaffold protein of the postsynaptic density (PSD), ... -
Synaptic physiology of the cochlear sound encoding
(2013-11-27)Sound intensity is encoded as action potential firing rates by spiral ganglion neurons. These neurons show different rate-level functions with different auditory thresholds, and are thought to collectively encode the large ... -
The role of attention and adaptation in shaping cortical representations and the perception of abrupt changes in the visual environment
(2017-11-22)The visual system receives a wealth of visual information about objects with changing features in time. Attention is a mechanism allowing us to prioritize the processing of relevant information at the expense of other ... -
The role of Calcium Binding Protein 2 in synaptic sound encoding and hearing
(2016-11-29)Hearing is a unique sensory feature providing the individual with acoustic information about the surrounding environment. Humans rely on hearing to localize potential dangers and it is essential for communication and social ... -
Theoretical analysis of membrane properties underlying action potential phase-locking in noise-driven cells
(2011-12-09)How does the brain work? This very broad and yet, very crucial and interesting question appealed scientists from various disciplines to itself. The fact that the operation of a system of ... -
Theoretical Studies of the Dynamics of Action Potential Initiation and its Role in Neuronal Encoding
(2011-08-08)In this thesis analytically solvable neuron models are constructed to study the influence of the initiation speed and location of AP (action potential) generation on the dynamical response ... -
Topological Optimization in Network Dynamical Systems
(2011-04-05)In this thesis we look at results concerning two separate topics.The first topic belongs to the general problem of reconstruction of interaction networks using only per-site information. ... -
Weakly Selective Training induces Specialization within Populations of Sensory Neurons
(2016-12-16)Many neurons in sensory pathways respond selectively to a narrow class of stimuli such as faces or specific communication calls. At the same time neural processing is robust to a large degree of natural variablity ...