Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Bayer, Thomas A. Prof. Dr."
Now showing items 1-7 of 7
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The role of N-truncated Aβ peptides in Alzheimer’s Disease
(2018-06-29)The N-terminally truncated pyroglutamate Aβ3−42 (AβpE3−42) and Aβ4−42 peptides are known to be highly abundant in the brain of Alzheimer’s disease (AD) patients. Both peptides show enhanced aggregation and neurotoxicity ... -
In Vitro and In Vivo Studies on Antibodies - N-terminally Truncated Abeta in the 5XFAD Mouse Model
(2015-05-29)Commonly used transgenic mouse models mimic Alzheimer´s disease (AD) to some extent but do as well display differences compared to the human AD phenotype. Growing evidence indicates that N-terminally truncated isoforms, ... -
Pathophysiological Characterization of intra‐ and extracellularly aggregated Amyloid Peptides in Dementias
(2013-06-28)Alzheimer’s Disease (AD) is the most common form of dementia in the elderly population and is neuropathologically characterized by hippocampal neurofibrillary degeneration, chronic inflammation as well as widespread ... -
The contribution of N-terminally modified amyloid beta to the etiology of Alzheimer's disease
(2012-09-07)A heterogeneou s mixture of amyloid beta (Aβ) isoforms exists in the brains of Alzheimer's disease (AD) patients. Despite decades of research, relatively little is known about the precise contribution of these variousAβ ... -
The 5XFAD mouse model: a tool for genetic modulation of Alzheime's disease pathology
(2012-01-25)AD mouse models contributed widely to our understanding of the pathophysiology of AD and represent invaluable tools in testing potential therapeutic interventions. In the present study, ... -
Studies on the Involvement of the Immune system in Alzheimer's disease
(2010-08-12)The main subject of this doctoral work is the role of the immune system in Alzheimer's disease (AD), and how its understanding may help to develop novel diagnostic and therapeutic options ... -
Pathological Alterations Induced by intraneuronal in Alzheimer’s Disease
(2010-01-18)Alzheimer’s disease (AD) is pathologically characterized by the deposition of amyloid beta (Aβ) and neurofibrillary tangles (NFT) consisting of hyperphosphorylated tau protein. Since familial mutations in proteins ...