Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Beißbarth, Tim Prof. Dr."
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Investigating the Importance of DNA Sequence for Nucleosome Positioning with Means of Machine Learning
(2024-07-09)Nucleosomes are protein complexes condensing DNA molecules to tight chromatin bun- dles to fit into the nucleus. The positioning of nucleosomes on the DNA mediates access to positions for DNA-binding proteins or enzymes ... -
Guiding Cancer Therapy: Evidence-driven Reporting of Genomic Data
(2018-11-26)Next Generation Sequencing (NGS) has been crucial for the breakthrough experienced by cancer genomics during the last decade. In turn, the knowledge gathered has fostered the development of targeted drugs and genomics-driven ... -
Data Integration of High-Throughput Proteomic and Transcriptomic Data based on Public Database Knowledge
(2017-05-17)With the advance of high-throughput methods enabling deep characterization of the cell on different cellular layers, ideas to combine different data types for inference of regulatory processes have emerged. Such integration ... -
Pathway and network analyses in context of Wnt signaling in breast cancer
(2016-03-01)A complex network of interplaying signaling pathways governs cell behavior and phenotype. Wnt signaling pathways are part of this network and play an important role in embryonic development as well as in carcinogenesis. ...