Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Dobbelstein, Matthias Prof. Dr."
Now showing items 1-17 of 17
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Non-canonical functions of the MDM2 oncoprotein
(2022-11-04)The tumour suppressor gene TP53 is mutated in ~50% of human cancers. The p53 protein is a transcription factor which is induced by several cellular stresses, such as ribosomal stress and DNA damage. Expression of its target ... -
MDM2 as a chromatin modifier
(2020-09-08)Since its discovery about 40 years ago, the transcription factor p53 has turned into the most extensively studied protein in the context of human cancers due to its essential role in promoting tumor suppression. P53 ... -
The impact of the integrated stress response on DNA replication
(2020-05-27)The integrated stress response (ISR) is activated following various stress stimuli which leads to the phosphorylation of the translation initiation factor eIF2alpha. Phosphorylation of eIF2alpha blocks cap−dependent ... -
The phosphatase MKP1 as a target to enhance replicative stress and apoptosis in tumor cells
(2016-04-29)DNA replication is a tightly regulated elementary process that ensures the exact duplication and transfer of genetic information to the next generation. However, a wide range of exogenous and endogenous genotoxic insults ... -
A regulatory network of Mdm2 and members of the Polycomb Group (PcG) family
(2016-01-22)The E3 ubiquitin ligase MDM2 is the most well-known physiological antagonist of the tumor suppressor P53. P53 induces cell cycle arrest or apoptosis in the case of DNA damage, whereas MDM2 targets it for proteasomal ... -
Role of endogenous retrovirus promoter activity in tumor suppression
(2015-06-03)Roughly 8% of the human genome consists of human endogenous retroviruses (HERVs). They are believed to be remnants of ancient retroviral infections of the germline that were passed on from one generation to the next over ... -
Combining gemcitabine with checkpoint kinase inhibitors to sensitize pancreatic tumors
(2015-04-15)Pancreatic tumor is one of the leading causes of cancer-related deaths in the world. Currently, the nucleoside analogue gemcitabine is the leading therapeutic drug for the treatment of pancreatic tumors. However, due to ... -
Role of 5-FU in DNA double strand break repair for improved targets in colorectal cancer therapy
(2015-04-14)Colorectal cancer (CRC) is the second leading cause of cancer related deaths in the world, and 5-Fluorouracil (5-FU) based regimens are chiefly employed for its therapy. Modern regimens, based on 5-FU in combination with ... -
Cooperation of p300 and iASPP in apoptosis and tumour suppression
(2014-11-04)Mutation or functional inactivation of tumour suppressors represents a key event in the transformation of cells and contributes to the development of cancer. P300 and CBP constitute two histone acetyltransferases with ... -
Drug Metabolism Determines Resistance of Colorectal Cancer to Resorcinol-Based HSP90 Inhibitors
(2014-11-04)Tumor cells are characterized by intrinsic proteotoxic stress and the accumulation of mutated proteins. Therefore, malignant cells depend on the activity of heat shock protein 90 (HSP90) much more than normal cells to ... -
Attenuated apoptosis as consequence of Epithelial Mesenchymal Transition
(2014-08-14)The developmental program of Epithelial Mesenchymal Transition (EMT) is assumed to be involved in tumor progression, enabling cancer cells to spread from the primary tumor and form metastasis in distant tissues. At least ... -
The ubiquitin ligase G2E3 modulates cell proliferation, survival and the DNA damage response
(2014-07-28)The chemotherapeutic cisplatin is widely used to treat various tumors. By inducing crosslinking of DNA, signaling and repair pathways are activated which are referred to as the DNA damage response (DDR). However, the ... -
The p53 homolog p73 takes hold of the male germ line – a novel function of TAp73 in protecting sperm cell adhesion, migration and maturation within the seminiferous epithelium of the testis
(2013-11-19)The p53 family of transcription factors possesses diverge functions in tumorigenesis and development. The evolutionarily conserved role of the family member p63 to protect the genetic stability of germ cells and influence ... -
The role of microRNAs in the p53 tumor suppressor pathway
(2011-12-16)MicroRNAs (miRNAs) are a class of small, non-coding, double-stranded RNA molecules. In metazoan cells, miRNAs recognize their target mRNAs by imperfectly complementary binding, leading to ... -
A novel phosphatase modulating the DNA damage response and the tumor suppressor p53
(2011-09-21)The cellular genome is constantly exposed to harmful endogenous and exogenous factors. Unrepaired DNA lesions and mismatches promote genomic instability, a major cause of cancer. Therefore, ... -
The accumulation of mutant p53 in human cancer cells
(2011-07-04)The tumor suppressor p53 is mutated in more than 50% of all human solid tumors. This comprises mostly single residue missense point mutations that entail a loss of p53 tumor suppressor ... -
Self-association of adenovirus 5 E1B-55 kDa as well as p53 is essential for their mutual interaction
(2009-12-15)P53 is at the center of the control systems that mediate the response to DNA damage, leading to cell cycle arrest or apoptosis. Virus infection can cause a DNA damage response through virus ...