Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Fischle, Wolfgang Prof. Dr."
Now showing items 1-7 of 7
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Development of a ‘tool box’ for generating designer nucleosomes in high throughput fashion
(2017-11-23)Post-translational modifications of histones within nucleosomes regulate cell development, cell maintenance and cellular response to external factors. According to the histone code hypothesis, each biologic reaction is ... -
Systematic analysis of heterochromatin modification readout
(2017-06-14)Modifications of the building units of chromatin - the histone proteins and DNA - direct the functional readout of the genome and are part of the so called “epigenome” (Fischle et al., 2003b; Kouzarides, 2007). Several ... -
Regulation of binding of HP1 associated complexes to chromatin and their role in transcription regulation in C. elegans vulva development
(2016-10-27)HP1 proteins are known to bind to H3K9me3 and thereby localize to heterochromatin. However, direct functions of HP1 in heterochromatin formation and maintenance are not clear. This is partially due to essentiality of HP1 ... -
Biochemical and functional differences of chromatin assembled replication-coupled or independent in Xenopus laevis egg extracts
(2012-04-12)Two main chromatin assembly pathways ensure the proper transmission of chromatin organization and chromatin-based information throughout the cell cycle. A replication-dependent (RD) pathway that couples chromatin assembly to ... -
Functional analysis of mitochondrial sirtuins in C. elegans and mammalian cells
(2011-09-15)Silent information regulator 2 (SIR-2) proteins, also referred to as sirtuins, are highly conserved NAD+-dependent protein deacetylases that are emerging to be important energy sensors and ... -
Identification and characterization of ADNP as a novel heterochromatin component
(2011-03-29)In eukaryotic cells genetic information in the form of long linear DNA fibers is stored in the cell nucleus. Time and tissue specific gene expression patterns are manifested by the combination ... -
Characterization of LIN-61 methyl mark binding and its function in C. elegans vulva development
(2011-03-21)In eukaryotic cells the genome is packaged into chromatin, which is composed of core histones (H2A, H2B, H3, H4), non-histone proteins and DNA. Packaging of DNA into distinct chromatin ...