Blättern GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach "Flügel, Alexander Prof. Dr." Betreuer

Blättern nach: : Betreuer | Gutachter | Betreuer & Gutachter

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    • Analysis of autoimmune lesions in grey matter 

      Hermann, Moritz (2018-06-14)
      In the present thesis I demonstrated that pathogenic TβSyn cells of wild-type and receptor-transgenic origins could be reliably generated and used for inducing passive transfer EAE; active EAE could be reproducibly induced ...

    • Autoimmune T cell - B cell interaction in experimental autoimmune encephalomyelitis 

      Flach, Anne-Christine (2015-03-17)
      Although Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are known as T cell-mediated autoimmune diseases, there is increasing evidence that B cells also play a critical role ...

    • Characterization of immune responses in the meninges 

      Merlini, Arianna (2022-06-14)
      Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), which is characterized by plaque-like demyelination in both white and grey matter and diffuse neurodegeneration. A T cell-driven ...

    • Crosstalk between the lung microenvironment and CNS autoimmunity 

      Cugota Canals, Roger (2023-05-08)
      The contribution of the lung in shaping CNS autoimmunity is gaining relevance in the last years. Central nervous system (CNS) reactive T cells can acquire in the lung the potential to invade the CNS in experimental ...

    • Elucidating the mechanisms of disease-triggering myelin-specific autoantibodies 

      Strauß, Judith (2019-10-24)
      Although T cells are commonly known to be the driving force of disease pathogenesis in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), B cells and their soluble effector molecules ...

    • Generation and analysis of T cell receptor transgenic rats to model CNS autoimmunity 

      Kitz, Alexandra (2014-01-27)
      Autoreactive T cells directed against CNS antigens seem to play an essential role at least in the initiation of multiple sclerosis. To improve our understanding about the function of pathogenic T cells in CNS autoimmunity ...

    • Role of antibodies in autoimmunity of the central nervous system 

      Cordero Gómez, César (2020-07-09)
      Although T cells are the main players in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), the role of B cells and their soluble effector molecules (antibodies) is being progressively ...

    • The role of the lung in shaping CNS autoimmunity 

      Hosang, Leon (2019-10-24)
      The lung was recently identified as a central site of T cell reprogramming in experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis (MS). While residing in the pulmonary tissue, central ...