Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Flügel, Alexander Prof. Dr."
Now showing items 1-8 of 8
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Crosstalk between the lung microenvironment and CNS autoimmunity
(2023-05-08)The contribution of the lung in shaping CNS autoimmunity is gaining relevance in the last years. Central nervous system (CNS) reactive T cells can acquire in the lung the potential to invade the CNS in experimental ... -
Characterization of immune responses in the meninges
(2022-06-14)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), which is characterized by plaque-like demyelination in both white and grey matter and diffuse neurodegeneration. A T cell-driven ... -
Role of antibodies in autoimmunity of the central nervous system
(2020-07-09)Although T cells are the main players in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), the role of B cells and their soluble effector molecules (antibodies) is being progressively ... -
The role of the lung in shaping CNS autoimmunity
(2019-10-24)The lung was recently identified as a central site of T cell reprogramming in experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis (MS). While residing in the pulmonary tissue, central ... -
Elucidating the mechanisms of disease-triggering myelin-specific autoantibodies
(2019-10-24)Although T cells are commonly known to be the driving force of disease pathogenesis in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), B cells and their soluble effector molecules ... -
Analysis of autoimmune lesions in grey matter
(2018-06-14)In the present thesis I demonstrated that pathogenic TβSyn cells of wild-type and receptor-transgenic origins could be reliably generated and used for inducing passive transfer EAE; active EAE could be reproducibly induced ... -
Autoimmune T cell - B cell interaction in experimental autoimmune encephalomyelitis
(2015-03-17)Although Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are known as T cell-mediated autoimmune diseases, there is increasing evidence that B cells also play a critical role ... -
Generation and analysis of T cell receptor transgenic rats to model CNS autoimmunity
(2014-01-27)Autoreactive T cells directed against CNS antigens seem to play an essential role at least in the initiation of multiple sclerosis. To improve our understanding about the function of pathogenic T cells in CNS autoimmunity ...