Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Kehlenbach, Ralph H. Prof. Dr."
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Nuclear transport of the nitric oxide synthase interacting protein (NOSIP)
(2023-05-23)Proteins that need to actively enter the nucleus are thought to be transported by a specific nuclear transport receptor (NTR), depending on the type of the nuclear localization signal (NLS). Some cargoes are reported to ... -
A nuclear export sequence in Nup214 promotes its targeting to the nuclear pore complex
(2020-10-29)The nuclear pore complex (NPC) controls the communication between the nucleus and the cytoplasm in a selective manner via a hydrophobic barrier involving phenylalanine-glycine (FG) repeats. Interactions with components of ... -
Analysis of Protein Transport to the Inner Nuclear Membrane
(2019-07-10)The eukaryotic cell is divided into different compartments. The biggest compartment is the nucleus which is formed by one lipid bilayer folded into two membranes: the outer nuclear membrane (ONM) and the inner nuclear ... -
Identification and Characterization of Importin 13 Substrates
(2018-05-09)Nuclear pore complexes embedded in the nuclear envelope regulate the bidirectional transport of macromolecules between the nucleus and the cytoplasm. Small molecules can rapidly move through the permeability barrier of the ... -
Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-binding Sites Involved in Nucleocytoplasmic Transport
(2015-09-09)Transport into and out of the nucleus occurs through nuclear pore complexes (NPCs) that are embedded in the nuclear envelope. NPCs are massive macromolecular complexes of around 125 kDa in vertebrates. Around 30 different ...