Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Lührmann, Reinhard Prof. Dr."
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Investigation of the effects of the splicing inhibitor Pladienolide B and cancer-related mutations in the SF3b1 protein on pre-mRNA splicing in vitro
(2020-06-11)Pre-mRNA splicing is catalyzed by the spliceosome. A highly dynamic, macromolecular RNP complex is formed out of the U1, U2, U4, U5 and U6 snRNPs and multiple snRNP proteins. During the early stages of spliceosome assembly, ... -
Smu1 and RED play an important role for the activation of human spliceosomes
(2019-07-08)In eukaryotes, pre-mRNA splicing is catalysed by the spliceosome, a highly complex and dynamic molecular machine, which assembles stepwise by the sequential recruitment of five small nuclear ribonucleoproteins (snRNPs) and ... -
Requirements for pre-catalytic B complex formation during exon- and intron-defined spliceosome assembly
(2015-10-07)In eukaryotes, most protein-coding genes are interrupted by non-coding sequences known as introns. The splicing of intronic sequences from a pre-mRNA is catalyzed by the spliceosome, an elaborate molecular machine formed ...