Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Melchior, Frauke Prof. Dr."
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Sumoylation of Nuclear Transport Receptors and the small GTPase Ran
(2013-08-08)Sumoylation has been linked to nucleocytoplasmic transport since the discovery of SUMO as a modifier of vertebrate RanGAP1, which is targeted to the nuclear pore complex (NPC) after sumoylation. The link between sumoylation ... -
Functional and mechanistic characterization of the F-box protein Fbxw5
(2011-08-09)Targeted protein ubiquitylation that occurs in eukaroytes is often performed by cullin-RING-based E3 Ubiquitin ligases (CRLs), a superfamily of E3s. These types of ligases are composed of ... -
Mechanisms of the intracellular localization of the SUMO-activating enzyme Aos1/Uba2
(2010-06-16)Dynamic posttranslational modification with ubiquitin related proteins of the SUMO (small ubiquitin-related modifier) family is an important cellular mechanism to alter the activity, abundance ... -
USPL1, a novel SUMO isopeptidase
(2009-06-23)Small Ubiquitin-like Modifiers (SUMO) are 10 kDa proteins that are covalently attached to hundreds of intracellular proteins to regulate their function. In mammals, three members of the ...