Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Moser, Tobias Prof. Dr."
Now showing items 1-14 of 14
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Developing tools for translational In-vivo cochlear optical stimulation
(2024-07-02)Utilizing optogenetic stimulation to target type I spiral ganglion neurons (SGNs) could promise an alternative to the currently employed electrical stimulation by current cochlear implants (CIs). Given light's spatial ... -
Quantitative molecular physiology at active zones of calyceal synapses of the auditory pathway
(2023-11-17)Bushy cells (BCs) of the anteroventral cochlear nucleus (aVCN) are the first relay station of ascending auditory information. Sound is transformed from mechanical to electrical stimuli by the inner hair cells of the cochlea ... -
Molecular physiology of sound encoding
(2021-10-26)Inner hair cells (IHC) are responsible for transforming mechanical sound-borne vibrations into electrical signals and conveying this information to the afferent spiral ganglion neurons (SGNs). Upon stimulation, the receptor ... -
Engineered genetic tools for directed gene regulation
(2021-07-28)Genetic manipulation or genetic engineering is the ability to modify the behaviour of a gene or group of genes. In biological research, since nucleic acids were shown to be responsible for control of cellular functions and ... -
Sound encoding at the first auditory synapse
(2020-08-21)The inner hair cell (IHC) synapse, the first relay station of the auditory system, is able to encode sound with sub-millisecond precision and without any signs of fatigue (Matthews and Fuchs, 2010; Pangršicˇ et al., 2012; ... -
Towards Optical Cochlear Implants: Behavioral and Physiological Responses to Optogenetic Activation of the Auditory Nerve
(2019-11-15)Cochlear implants (CIs) constitute the interface between the sound-deprived brain of patients suffering from sensorineural hearing loss and the auditory scene surrounding them. By electrically stimulating the auditory nerve ... -
Optogenetic stimulation of the cochlea
(2019-07-15)Optogenetic stimulation of the auditory nerve is a promising alternative to restore hearing. Since light can be focused on the target tissue, the optical cochlear implant (oCI) might support a major improvement in frequency ... -
Ultrafast Multichannel Optogenetic Stimulation of the Auditory Pathway for Optical Cochlear Implants
(2019-01-14)In case of profound sensorineural hearing loss and deafness, cochlear implants (CIs) partially restore hearing and provide missing auditory information to the brain. Electrical stimulation of the spiral ganglion neurons ... -
Molecular physiology of synaptic sound encoding at the first auditory synapse
(2018-03-20)To achieve accurate encoding of sounds, inner hair cell (IHC) ribbon-type synapses are highly specialized to release synaptic vesicles (SVs) with high rates and temporal precision. A sophisticated, by far not yet fully ... -
Molecular physiology of signal transmission along the auditory pathway
(2017-12-13)Signal transmission lies at the core of brain function. Understanding how information is transferred from one neuron to the other is the first step toward deciphering not just normal brain processing but the pathology of ... -
The role of Calcium Binding Protein 2 in synaptic sound encoding and hearing
(2016-11-29)Hearing is a unique sensory feature providing the individual with acoustic information about the surrounding environment. Humans rely on hearing to localize potential dangers and it is essential for communication and social ... -
Confocal Imaging of Calcium Signal and Exocytosis at Individual Hair Cell Synapses
(2013-12-17)Hearing over a wide range of sound intensities is thought to require complementary coding by functionally diverse spiral ganglion neurons (SGNs), each changing its firing rate only over a limited sub-range. The means for ... -
Synaptic physiology of the cochlear sound encoding
(2013-11-27)Sound intensity is encoded as action potential firing rates by spiral ganglion neurons. These neurons show different rate-level functions with different auditory thresholds, and are thought to collectively encode the large ... -
Expression and function of Rab3 interacting molecules and clarin-1 in inner hair cells
(2013-09-04)Hearing depends on faithful synaptic transmission at the inner hair cell (IHC) ribbon synapse, which is orchestrated by active zone proteins. RIM (Rab3 Interacting Molecules) is one of the active zone proteins and proposed ...