Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Outeiro, Tiago Fleming Prof. Dr."
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Investigations of Synaptic Alterations in Models of Parkinson’s Disease
(2024-07-02)Alpha-synuclein (aSyn) is a presynaptic protein implicated in physiological synaptic roles, though its precise function is largely unknown. In Parkinson's disease (PD), the initial pathological events often involve synaptic ... -
Systematic comparison of the molecular mechanisms underlying the spreading of pathology in different neurodegenerative diseases
(2021-10-19)Misfolding and accumulation of disease-related proteins are common hallmarks among several neurodegenerative diseases. This phenomenon causes the progressive loss of cognitive and motor functions correlated with specific ... -
The role of alpha-synuclein on transcriptional deregulation in Parkinson’s disease
(2018-08-31)Parkinson’s disease (PD) is a complex neurodegenerative disorder that manifests through a broad ran ge of motor and non - motor symptoms. Alpha - synuclein (aSyn) is the major ... -
The interplay between α-synuclein and Rab GTPases: Insights into the molecular basis of synucleinopathies
(2015-03-24)Ageing related diseases become of ever more significance with the demographic shift currently prevalent in society. Dementia and movement disorders impact individuals and families alike, as the progressive decline in ...