Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Pöhlmann, Stefan Prof. Dr."
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Host cell entry and antibody evasion of SARS-CoV-2 and animal sarbecoviruses
(2024-11-29)The emergence of SARS-CoV-2 has heightened global awareness of coronaviruses, following previous outbreaks of SARS-CoV and MERS-CoV, which originated in animals and were transmitted to humans, causing severe disease. ... -
Novel production system for influenza A virus-derived defective interfering particles and analysis of antiviral activity
(2020-09-24)Influenza A virus (IAV) increases morbidity and mortality rates and novel antivirals are needed to combat the virus. Errors of the viral polymerase lead to the generation of defective RNAs. These DI-RNAs may interfere with ... -
Characterization of host cell factors used by emerging coronaviruses for entry into target cells
(2020-07-24)Human coronaviruses (HCoV) mainly cause common cold-like symptoms. However, in the last two decades the emerging coronaviruses the severe acute respiratory syndrome coronavirus (SARS-CoV) (in 2002), Middle East respiratory ... -
Interactions of the Ebola virus glycoprotein with host cell factors during viral entry and release
(2019-03-28)Ebola virus disease (EVD) is a severe disease that affects humans and non-human primates. The recent EVD epidemic in West Africa shows that EVD poses a severe threat to human health. EVD is caused by Ebola virus (EBOV) and ... -
Activation of the influenza virus hemagglutinin by type II transmembrane serine proteases
(2016-04-04)The influenza virus hemagglutinin (HA) mediates viral entry into target cells. HA is synthesized as an inactive precursor and depends on proteolytic processing by host cell proteases to become active. TMPRSS2, a member of ...