Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Papantonis, Argyris Prof. Dr."
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Resolving chromatin interaction and transcriptional networks in mammalian nuclei
(2024-08-15)The nucleus is a highly organized machine. Chromatin organization, transcription, and RNA processing are working harmoniously in a specialized but communicative way to pass the information from DNA to mature RNA. In the ... -
Reorganization of the Senescent Genome via Spatial CTCF Clustering
(2023-07-13)Cellular senescence is now understood to be a major hallmark of the aging process. Senescence can be induced by many stress factors, including telomere shortening, DNA damage and tumor- suppressor genes activation and ... -
Dependency of 3D chromatin folding on RNA polymerase II at different cell cycle stages
(2023-07-13)In human cells, the genetic information is organised in a multilayer fashion. During the cell cycle, chromatin undergoes dramatic structural changes. For proper inheritance, chromatin is compacted to chromosomes in ... -
Chromatin reorganization, signaling responses and non-coding RNA regulators in homeostasis and senescence
(2022-04-21)In mammalian cells, a relatively limited fraction of genetic information is utilized in a variety of ways to give rise to distinct cellular phenotypes. Thus, the genotype essentially acts as input for multilayered regulatory ... -
Dissecting the molecular mechanism and spatiotemporal dynamics controlling senescence entry
(2021-01-21)Senescence represents a programmed cell cycle arrest against aberrant proliferation and tumour development due to accumulated genotoxic or metabolic stress. The tumour-suppressive properties of senescence attracted the ...