Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Reichardt, Holger Prof. Dr."
Now showing items 1-5 of 5
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Modulation of allergic airway inflammation by glucocorticoids
(2014-03-06)A crucial step in the development of improved drugs for asthma therapy is a thorough understanding of the mechanisms, which are important for effective treatment, and the identification of target cells in asthma pathogenesis. ... -
Role of the Hedgehog receptor Patched1 in the development and function of T lymphocytes
(2013-06-18)The hedgehog signalling pathway is a highly conserved key regulator of animal development and required for homeostasis of adult tissues both in invertebrates and vertebrates. In addition, a large number of studies have ... -
Endocrine control of T cell function and its implications for the pathogenesis of neuroinflammatory diseases
(2013-06-17)Insulin and GCs are two important endocrine regulators of mammalian body homeostasis and both impact on immune cell functions. Whereas GCs are in widespread use for the treatment of autoimmune diseases since the late 1950s, ... -
Myeloid cell-specific ablation of the mineralocorticoid receptor attenuates experimental autoimmune encephalomyelitis
(2013-02-12)The mineralocorticoid receptor (MR) plays an essential role in regulating fluid and electrolyte homeostasis. Amongst hematopoietic cells, also macrophages express the MR but, unlike kidney or colon, they do not co-express ... -
Molecular and cellular mechanisms of glucocorticoids in the treatment of acute graft-versus-host disease
(2012-11-19)Haematopoietic stem cell transplantation (HSCT) is often the only curative therapy for haematopoietic malignancies and some inherited diseases of the haematopoietic system. A major side effect of HSCT and a cause of morbidity ...