Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Schlüter, Oliver Dr. Dr."
Now showing items 1-9 of 9
-
A cortical hierarchy for differential GABAergic circuit motifs as targets for stress-induced alterations in endocannabinoid signaling
(2021-09-17)Aberrant endocannabinoid (eCB) signaling has been implicated in the pathophysiology of different stress-related psychiatric diseases, such as schizophrenia, depression, and anxiety disorders. Such eCB signaling is triggered ... -
Cocaine-induced synaptic changes in the nucleus accumbens: role in drug-motivated behaviour and relapse risk
(2021-05-17)Chronic drug use creates robust and durable memories which, even after years of abstinence, can be reawakened by drug-associated cues and trigger craving and relapse. Addictive drugs elevate extracellular dopamine levels ... -
Circuit refinement in mouse visual cortex during development
(2019-02-01)Circuit refinement is an important developmental process ensuring correct wiring of synaptic connections. During circuit refinement, favorable connections are generated or strengthened while unfavored ones are weakened or ... -
Norepinephrine induces internalization of Kv1.1 in hippocampal neurons
(2017-08-08)Norepinephrine (NE), a catecholamine produced by dopamine β-hydroxylase, is released either as a hormone from the adrenal medulla into the blood, or as a neurotransmitter in the brain. Norepinephrine signaling serves as a ... -
Cocaine-induced synaptic plasticity in the nucleus accumbens and drug-associated behavior - An unexpected dissociation
(2016-05-19)Drugs of abuse such as cocaine are known to hijack synaptic plasticity mechanisms of brain circuits underlying motivated behavior. A common mechanism of drugs of abuse is to elevate extracellular dopamine levels in the ... -
Roles of PSD-93 and environmental enrichment in cortical synapses
(2015-11-10)During neurodevelopment several structural, molecular and functional changes take place in the brain to promote its maturation. These changes occur at multiple levels, including changes in protein expression, in the strength ... -
Role of DLG-MAGUKs in surface NMDAR localization and its patho-physiological functions
(2014-10-16)The post-synaptic side of an excitatory synapse is characterized by an electron-dense, highly dynamic architecture of proteins, called the post-synaptic density or PSD. PSDs comprises of a diverse group of proteins, from ... -
Role of PSD-95 in synaptic maturation and visual cortex plasticity
(2014-08-29)PSD-95 belongs to the family of DLG-MAGUKs (Discs-large membrane-associated guanylate kinases), and it plays an important role in organizing postsynaptic signaling and synaptic transmission in excitatory synapses. The ... -
The Role of PSD-95 and Kinase Interactions in Synaptic Transmission
(2013-08-07)During development various structural and molecular changes take place in the brain leading to its maturation. These changes occur at multiple levels, including the alterations in protein expression level of single cells ...