Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Schmidt, Christoph F. Prof. Dr."
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Molecular DNA Sensors to Measure Distribution of Cytoskeletal Forces
(2020-08-24)Actin, a major cytoskeletal biopolymer in eukaryotic cells, is crosslinked into networks of filaments and bundles. These networks are largely responsible for the maintenance of cellular shape, rigidity, and mechanical ... -
Mechanical Properties of the lch5 Organ in the Drosophila Larva
(2017-09-08)I begin with a brief account of the topic of mechanosensation, followed by an outline of how the project evolved. The experimental techniques used and their rationale are described. The section ends with a short description ... -
Investigation of voltage- and light-sensitive ion channels
(2016-08-09)In this work, the properties of ion channels in biological membranes are characterized. Two systems are investigated: The conductance changes of the membrane of the axon initial segment (AIS) due to fast sodium channels, ... -
Intracellular micromechanics of the syncytial Drosophila embryo
(2015-09-28)A developing embryo is a striking and fascinating example of self-organization and collective behavior of biological matter. In the presented work, I investigated the cytoplasmic interior of Drosophila melanogaster ... -
Single-molecule measurements of Kinesin motor proteins
(2014-03-13)This thesis covers the developments and new findings on different regulatory processes in Kinesin-5 motor proteins. The first two chapters give a general introduction into motor proteins and some of the well established ... -
Lab-on-chip design to characterize pore-spanning lipid bilayers
(2013-11-26)A powerful approach to study membrane proteins is the reconstitution in model membranes. Methods for arti cial bilayer formation are e.g. membranes on a solid support, or the classical BLM. In this project, the focus was ... -
High-bandwidth microrheology of cytoskeletal networks
(2012-02-08)The understanding of the material properties, the organization and the assembly of the cytoskeleton remains challenging. In this thesis the viscoelastic properties of cytoskeletal networks ...