Blättern GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach "Simons, Mikael Prof. Dr." Betreuer
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Microglia activation and regulation of remyelination in the central nervous system
(2019-08-21)In the central nervous system, remyelination requires the proliferation and migration of oligodendrocyte progenitor cells (OPCs) to the lesions, and the differentiation of OPCs into oligodendrocytes that remyelinate the ... -
Myelin pruning by microglia during development
(2019-04-26)Myelin is a lipid rich membrane produced by oligodendrocytes in the central nervous system. During development, oligodendrocyte precursor cells find their target axons and start to wrap their processes around axons, thereby ... -
Molecular Interactions between Neurons and Oligodendrocytes during Myelin Formation
(2019-04-23)Myelin is a multi-layered membrane wrapped around axons. It allows fast nerve conduction and provides the axon with trophic support. In the central nervous sys- tem (CNS), oligodendrocytes form multiple myelin sheaths. ... -
Identification of a unique oligodendrocyte subpopulation in mouse brain
(2018-10-10)Oligodendrocytes in the central nervous system (CNS) ensheath axons with myelin and are originated from migratory and proliferative progenitor cells, so-called oligodendrocytes progenitor cells (OPCs). While immunoreactivity ... -
Iron Homeostasis in Neuron-Glia Interaction
(2018-03-15)One major function of glial cells is to support neurons and create an environment that allows fast signal propagation. However, when neurons are ensheathed, they also get isolated from the extracellular environment and can ... -
Biogenesis and maintenance of cytoplasmic domains in myelin of the central nervous system
(2017-02-27)Myelin is a multi-lamellar membrane structure, produced by oligodendrocytes which are special glial cells, that myelinate axons in the central nervous system (CNS) (Aggarwal, Yurlova, & Simons, 2011; Vassall, Bamm, & Harauz, ... -
The molecular mechanisms of myelin disassembly
(2016-08-26)Myelin is characterized by stacking of multiple layers of membrane compacted by MBP. The breakdown of myelin is a pathological hallmark of several autoimmune diseases of the nervous system. To assess the myelin fragmentation ... -
Role of microglia in myelin turnover
(2016-07-11)During development oligodendrocytes in the central nervous system (CNS) produce large amount of membrane to generate myelin which wraps around the axons. The synthesis, maintenance and turnover of such enormous amounts of ... -
Lipid organisation and dynamics in the myelin membrane sheets
(2014-07-25)Myelin is a unique lipid-enriched membrane, produced by oligodendrocytes in the central nervous system, that is enwrapped around axons in the multilayered fashion to ensure a swift saltatory conduction of the neuronal ... -
Mechanisms underlying the CNS myelination: A molecular and morphological analysis of the wrapping process
(2014-04-17)Central nervous system myelin is a multilayered membrane sheath generated by oligodendrocytes for rapid axonal electrical impulse propagation. Both light and electron microscopy have been used to describe morphological ... -
Molecular mechanisms of lipid-rich myelin membrane sheet formation
(2013-02-13)Myelin is a membrane of vital importance. In the vertebrate nervous system, it promotes rapid conduction of nerve impulses via insulating the axons. To act as an insulator, myelin needs to assemble into a stable, lipid-rich ... -
Neurodegeneration in toxin-mediated demyelinating animal models of Multiple Sclerosis
(2012-11-05)Myelin is produced by a specialized membrane of oligodendrocytes in the CNS. This multilayered structure enwraps axons, providing them with trophic support and facilitates the fast transmission of electric signals. To ... -
Myelin Membrane Growth and Organization in a Cellular Model System (EN)
(2011-01-19)This thesis addresses the two fundamental questions of myelin biogenesis: how the myelin membrane is extended and how it acquires its specific lateral organization. Myelin is a multilayered ...