Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Staiger, Jochen F. Prof. Dr."
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Functional connectivity of the L2/3 VIP-to-L4 SST cell circuit motif in the primary somatosensory and visual cortices of mouse
(2024-02-19)The mammalian cortex is comprised of a multitude of cell types, wired together in intricate circuit motifs, which are recruited during different behavioral scenarios. Broadly speaking, neocortical neurons can either be ... -
Intracortical mechanisms compensating weakened thalamic input in the hyperexcitable somatosensory cortex of reeler mutant mice.
(2022-01-21)In the severely disorganized reeler primary somatosensory cortex, thalamocortical axons manage to target layer 4-fated neurons. Although the reeler somatosensory cortex maintains proper activation in response to sensory ... -
Brain-wide connectivity of molecularly defined GABAergic neurons in mouse barrel cortex visualized with optimized rabies virus tracing
(2020-03-16)Cortical GABAergic neurons are indispensable in controlling the activity of cortical networks. Parvalbu- min (PV), somatostatin (SST) and vasoactive intestinal polypeptide (VIP) expressing neurons are three main classes ... -
A guardian of balance: the role of BAF chromatin remodeling complex in astrogliogenesis during mouse forebrain development
(2019-12-20)In the human central nervous system, astrocytes vastly outnumber neurons and regulate a host of physiological processes critical to its function. Astrocytes form a functional syncytium tiling the brain with minimal overlap ... -
From inside-out to outside-in: cortical lamination development in the Reelin-deficient neocortex
(2019-03-15)The adult mammalian neocortex is divided into six vertical layers, as well as into numerous specialized tangential areas that are defined by distinct cytoarchitectures and specific wiring patterns. Precise neocortical ... -
Ultrastructural Characterization of The Output of VIP Expressing Interneurons in Mouse Barrel Cortex
(2017-11-15)Based on this preliminary result, a quantitative immunoelectron microscopy study was adopted to comprehensively characterize the output of VIP interneurons across the whole laminae of mouse barrel cortex. Using VIPcre/YFP ... -
Untangling neuronal diversity: a quantitative electrophysiological and morphological characterization of VIP expressing interneurons
(2017-03-21)VIP expressing interneurons are an essential component of cortical circuitry. This distinct subgroup of inhibitory interneurons was always described as the most heterogeneous subgroup of inhibitory interneurons. However, ... -
Functional connectivity of layer II/III and V GABAergic Martinotti cells in the primary somatosensory (barrel) cortex of mice
(2016-02-16)Although they represent only a small portion of cortical neurons, inhibitory interneurons take a major role in controlling the activity of cortical excitatory cells and, hence, cortical processing. The interaction of ...