Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Urlaub, Henning Prof. Dr."
Now showing items 1-10 of 10
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Characterization of Ca2+-triggered (de)ubiquitination events in depolarized synaptosomes by mass spectrometry
(2024-08-15)Communication between neurons takes place at synapses, where the transmission of information from the presynaptic neuron to the postsynaptic cell involves the Ca2+-regulated fusion of synaptic vesicles (SVs) with the ... -
Implementation of chemical protein-nucleic acid cross-linking into mass spectrometric workflows and mass spectrometric database searches
(2021-11-22)Protein nucleic acid interactions play a pivotal role in cells, from transcription to translation. Functions of proteins in protein nucleic acid interactions are diverse: histones are responsible for the packaging of the ... -
Post-Translational Protein Modifications involved in Exo- and Endocytosis of Synaptic Vesicles
(2021-10-26)Neurotransmitter release is a key step that enables information flow between the pre- and post-synapse. However, regulation of the neurotransmitter release remains an intricate and widely unexplored matter despite recent ... -
Identification of peptide-RNA heteroconjugates by mass spectrometry
(2020-10-12)Proteins and nucleic acids are two of the major constituents of life and their interplay is at the center of most biological processes. A deep understanding of the interaction between these biomolecules is crucial for ... -
A comprehensive characterization of brain and retina synaptic vesicle proteome by quantitative mass spectrometry.
(2017-06-07)Synaptic vesicles (SVs) are essential organelles for the transfer of information between a pre-synaptic nerve terminal and a post-synaptic target. SVs release their neurotransmitter content into the synaptic cleft in a ... -
Quantitative phosphoproteomics for studying B-cell receptor signaling in Burkitt’s lymphoma
(2017-02-16)Protein phosphorylation plays an important role in transmitting cellular signals. Phosphorylation has been mostly characterized by hypothesis-driven and low-throughput approaches in the past. However, novel phosphorylation ... -
Investigation of prokaryotic immune defense system with quantitative and structural mass spectrometry
(2016-02-26)Bacteria and archaea have evolved an adaptive and heritable immune defense system comprising a CRISPR (clustered regularly interspaced short palindromic repeats) locus and Cas (CRISPR-associated) proteins that targets ... -
MS-based quantitative analysis of the CRM1 export pathway and spatial proteomics of the Xenopus laevis oocyte
(2015-09-22)Nuclear export is a vital cellular process, which supplies the cytoplasm with essential biological macromolecules, such as matured tRNAs and ribosomal subunits. This process is carried out by a set of proteins called ... -
Investigation of protein-RNA interactions by UV cross-linking and mass spectrometry: methodological improvements toward in vivo applications
(2014-04-07)Protein–RNA complexes play key roles in a variety of cellular functions such as gene expression and its regulation. One frequently applied method for the investigation of direct protein–RNA interactions is UV induced ... -
Systematic analysis of the interactome of modified chromatin
(2013-09-13)Regulation of chromatin composition and structure is crucial for maintaining genome integrity and execution of the wide array of functions related to gene regulation and downstream cell signaling. Chemical modifications ...