Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Zweckstetter, Markus Prof. Dr."
Now showing items 1-9 of 9
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Formation, regulation and dynamics of phase separated postsynaptic density condensates with Tau and Fyn
(2024-11-22)Alzheimer’s disease is characterized by memory loss and cognitive impairments. The cognitive deficits and synaptic dysfunction are associated with the excitotoxicity mediated by NMDA (N-methyl-D-aspartate) receptors on the ... -
Exploring the human Hsp70-Hop-Hsp90 system for Tau recognition
(2022-03-22)Molecular chaperones are diligent helpers of the cell that ensure a well-balanced proteome by regulating protein production, protein folding, refolding and holding as well as protein degradation. In doing so, molecular ... -
Molecular insights into the Tau-actin interaction
(2018-05-04)Tau protein is classically considered as a neuronal microtubule-associated protein that stabilizes microtubules and supports the outgrowth of axons. The protein can modulate the transport of vesicles and organelles along ... -
NMR Spectroscopy of the Tau-Microtubule Interaction
(2015-12-10)Tau is an intrinsically disordered, microtubule associated protein and is responsible for the promotion of microtubule (MT) formation and stabilization. The human Tau protein has six different isoforms, which are expressed ... -
Paramagnetic tools for the structural analysis of high molecular weight proteins
(2015-12-10)Paramagnetic effects provide important structural and dynamic information of biomolecules. However, the attachment of lanthanides through small chelating organic molecules to proteins (the most common way to obtain ... -
Residue level characterization of molecular interactions of intermembrane space domains governing the preprotein import into the mitochondrial matrix
(2014-12-10)Mitochondrial matrix targeting proteins are translated as preproteins (carrying an N-terminal 20-50 residue presequence) in the cytoplasm. Post-translationally, they are imported into the mitochondrial matrix through ... -
Solution NMR-based characterization of the structure of the outer mitochondrial membrane protein Tom40 and a novel method for NMR resonance assignment of large intrinsically disordered proteins
(2014-05-08)This dissertation is composed of two parts. In the first part, the characterization of the structure of liposome-embedded Tom40 using a novel hydrogen/deuterium (H/D) exchange method is described. In the second part, a new ... -
Structural insights into Arginine-Serine rich proteins and N-H spin-spin coupling constants
(2013-11-27)This thesis is constituted of two parts. In the first part of this thesis, I studied the structural phenomena of SR protein phosphorylation. The serine/arginine-rich (SR) protein family plays multiple functions in the whole ... -
Molecular Mechanisms of Tau Protein Aggregation Inhibition
(2013-11-11)Of all neurodegenerative diseases, Alzheimer´s Disease is the most widespread dementia syndrome, exhibiting progressive memory loss and intellectual abilities. One of the pathological hallmarks of this disease is associated ...