Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Bayer, Thomas A. Prof. Dr."
Now showing items 1-15 of 15
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The contribution of oligodendrocytes to amyloid and tau pathologies in mouse models of Alzheimer’s disease
(2024-03-18)Oligodendrocytes (OLs) are the myelinating glia of the CNS and are capable of metabolically supporting long axonal projections by providing local fuel production. OL and myelin health, however, start degrading around the ... -
Mechanisms underlying postoperative pain – A translational study
(2024-02-05)The current focus on pain following surgery is in understanding the mechanisms behind it to develop methods to reduce its impact in patients. Surgery is necessary for treating several diseases and conditions; therefore, ... -
Sleep control by TFAP2a and TFAP2b transcription factors in mice
(2023-01-31)Sleep is a universal behavior that exists across species. We previously found that deletion of transcription factor APTF-1 induces sleep loss in C. elegans and Drosophila. In mammals, sleep has two states: rapid eye movement ... -
Therapeutic approaches for two distinct CNS pathologies
(2020-06-19)This work summarizes the analysis of two distinct therapeutic approaches for the central nervous system (CNS) pathologies, Pelizaeus-Merzbacher disease (PMD) and Glioblastoma multiforme (GBM). PMD is a severe leukodystrophy ... -
Investigation of myelin maintenance and turnover by inducible MBP knock-out in adult mice
(2019-11-11)The turnover and maintenance of myelin in the adult CNS Myelin is a multilayered membrane structure generated by oligodendrocytes in the CNS that insulates and supports axons. While most of the oligodendrocyte population ... -
Onset and Progression of Neurodegeneration in Mouse Models for Defective Endocytosis
(2019-10-25)Neurodegenerative diseases have become an increasing problem in our aging society. Many studies have addressed these complex diseases in the recent years. Scientists have learned a lot about specific proteins, their ... -
Mechanisms of synaptic plasticity mediated by Clathrin Adaptor-protein complexes 1 and 2 in mice
(2019-06-13)Clathrin adaptor protein complexes 1 and 2 (AP1 and AP2) have essential functions in synaptic vesicle (SV) recycling. In all cell types and tissues, AP1 mediates TGN/endosome protein sorting via clathrin-coated-vesicles ... -
Myelin pruning by microglia during development
(2019-04-26)Myelin is a lipid rich membrane produced by oligodendrocytes in the central nervous system. During development, oligodendrocyte precursor cells find their target axons and start to wrap their processes around axons, thereby ... -
Genetic manipulation of CNS cholesterol metabolism and its effects on cerebral β-amyloidosis
(2019-03-07)Accumulating evidence implicates cholesterol metabolism in the pathogenesis of Alzheimer’s disease (AD). However, the underlying mechanisms are not well understood. In the brain, cholesterol is synthesized locally by ... -
The role of N-truncated Aβ peptides in Alzheimer’s Disease
(2018-06-29)The N-terminally truncated pyroglutamate Aβ3−42 (AβpE3−42) and Aβ4−42 peptides are known to be highly abundant in the brain of Alzheimer’s disease (AD) patients. Both peptides show enhanced aggregation and neurotoxicity ... -
Characterization of Ambra1 heterozygous mice as genetic mouse model of female-specific autism
(2017-09-11)Autism is known as a heritable neurodevelopmental disorder, diagnosed prior to the age of three years in humans based on three major domains: (1) impairment in social interaction (2) communication deficits (3) restricted ... -
Characterization of FBXO7 (PARK15) knockout mice modeling Parkinsonian-Pyramidal Syndrome
(2017-04-19)The second most common neurodegenerative disease, Parkinson’s disease (PD), is caused by loss of dopaminergic neurons in the substantia nigra leading to impaired motor control. Genetic analyses have revealed recessively ... -
In Vitro and In Vivo Studies on Antibodies - N-terminally Truncated Abeta in the 5XFAD Mouse Model
(2015-05-29)Commonly used transgenic mouse models mimic Alzheimer´s disease (AD) to some extent but do as well display differences compared to the human AD phenotype. Growing evidence indicates that N-terminally truncated isoforms, ... -
Modeling neuropsychiatric phenotypes in mice in the frame of translational neuroscience
(2014-01-20)Neuropsychiatric disorders, such as autism spectrum disorders (ASD), schizophrenia, anxiety disorders, major depression and substance use disorders are highly prevalent and contribute to disease burden worldwide. Accumulating ... -
The 5XFAD mouse model: a tool for genetic modulation of Alzheime's disease pathology
(2012-01-25)AD mouse models contributed widely to our understanding of the pathophysiology of AD and represent invaluable tools in testing potential therapeutic interventions. In the present study, ...