Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Behr, Rüdiger Prof. Dr."
Now showing items 1-10 of 10
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Host cell entry and antibody evasion of SARS-CoV-2 and animal sarbecoviruses
(2024-11-29)The emergence of SARS-CoV-2 has heightened global awareness of coronaviruses, following previous outbreaks of SARS-CoV and MERS-CoV, which originated in animals and were transmitted to humans, causing severe disease. ... -
Development of Methods for Cardiac Tissue Characterization Using Magnetic Resonance Imaging in Animal Models
(2024-09-26)Cardiovascular diseases (CVDs) are the primary cause of death and disability globally. The progression of CVDs is often associated with functional and structural alterations, including reduced myocardial contractility, ... -
Identification of host factors for the replication of the Kaposi’s sarcoma- associated herpesvirus (KSHV) and the related rhesus monkey rhadinovirus (RRV)
(2024-07-23)Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human tumor virus. It is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. KSHV is known to interact with several different ... -
Characterisation of primate primordial germ cells in vitro
(2024-06-17)Primordial germ cells (PGCs) are embryonic precursors of sperm and eggs, responsible for passing on genetic and epigenetic information throughout the generations. For certain mammalian species, the development of PGCs can ... -
Characterization of testosterone and androgen receptor action in human and rhesus macaque heart muscle cells
(2024-03-26)Androgens are sex steroid hormones that influence various processes in reproductive tissues and peripheral organs. Their lipophilic nature enables free diffusion through the plasma membrane. In the cytoplasm, testosterone ... -
Mechanisms underlying age-related decline in mammalian female fertility
(2024-03-05)Reproductive longevity is crucial for fertility and impacts healthy ageing. Unlike in men, fertility in women starts to decline several decades before other signs of ageing set in. Female fertility is restricted by a limited ... -
Phenotypic and Functional Characterization of Natural Killer Cell Receptors in Human and Rhesus macaque
(2024-02-05)Activating killer immunoglobulin-like receptors (KIRs) cannot transmit signals directly but through signaling motifs. Since human activating KIRs lack signaling molecules, their transmembrane lysine residue pairs with ... -
Role of predisposing genetics, telomere signaling and crosstalk of cardiac fibroblasts and cardiomyocytes in a pluripotent stem cell model of dilated cardiomyopathy
(2023-02-16)Despite rapid scientific and medical advances, cardiovascular diseases represent a major threat to human health worldwide. Among these, cardiomyopathies are one of the leading causes of heart failure. Dilated cardiomyopathy ... -
Analysis of splice-defect associated cardiac diseases using a patient-specific iPSC-cardiomyocyte system
(2021-01-15)The induced pluripotent stem cell (iPSCs) based cardiomyocyte system (iPSC-CMs) is a powerful tool to serve as a human in vitro model for cardiac diseases. Dilated cardiomyopathy (DCM) and left ventricular non-compaction ... -
Optimization and application of Trim-Away for studying a liquid-like spindle domain in mammalian oocytes
(2019-10-01)In this thesis, I reported a membraneless structure that permeated a major region of the female meiotic spindle and formed droplet-like protrusions around the spindle poles. Proteins within this previously unknown structure ...