Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Beißbarth, Tim Prof. Dr."
Now showing items 1-8 of 8
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Investigating the Importance of DNA Sequence for Nucleosome Positioning with Means of Machine Learning
(2024-07-09)Nucleosomes are protein complexes condensing DNA molecules to tight chromatin bun- dles to fit into the nucleus. The positioning of nucleosomes on the DNA mediates access to positions for DNA-binding proteins or enzymes ... -
Computational biology and bioinformatic methods in neuropsychiatric research: From autoimmunity to cognition and erythropoietin
(2024-06-24)Research in neuropsychiatry has greatly developed in terms of complexity, both in the questions addressed and the datasets used. Advances in computational biology and bioinformatic methods have been essential to this ... -
Statistical methods for biological sequence analysis for DNA binding motifs and protein contacts
(2021-09-21)Over the last decades a revolution in novel measurement techniques has permeated the biological sciences filling the databases with unprecedented amounts of data ranging from genomics, transcriptomics, proteomics and ... -
Bioinformatics analysis of multi-omics data elucidates U2 snRNP function in transcription
(2021-08-16)Transcription by RNA polymerase II (Pol II) is an important step in cell function and regulation. Pol II transcription has been shown to be coupled to pre-mRNA splicing, but the underlying mechanisms remain poorly ... -
Guiding Cancer Therapy: Evidence-driven Reporting of Genomic Data
(2018-11-26)Next Generation Sequencing (NGS) has been crucial for the breakthrough experienced by cancer genomics during the last decade. In turn, the knowledge gathered has fostered the development of targeted drugs and genomics-driven ... -
Developmental Studies on Eye Types and Pedipalps in Parasteatoda tepidariorum
(2017-12-21)Arthropods are by far the most species rich phylum in the animal kingdom and their evolutionary success is at least in part rooted in their diverse morphology. Despite these morphological differences, arthropods share a ... -
Data Integration of High-Throughput Proteomic and Transcriptomic Data based on Public Database Knowledge
(2017-05-17)With the advance of high-throughput methods enabling deep characterization of the cell on different cellular layers, ideas to combine different data types for inference of regulatory processes have emerged. Such integration ... -
Pathway and network analyses in context of Wnt signaling in breast cancer
(2016-03-01)A complex network of interplaying signaling pathways governs cell behavior and phenotype. Wnt signaling pathways are part of this network and play an important role in embryonic development as well as in carcinogenesis. ...