Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Bennati, Marina Prof. Dr."
Now showing items 1-20 of 21
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Development of Analysis- and Simulation-Routines for ENDOR Spectroscopy
(2024-10-04)Electron paramagnetic resonance (EPR) spectroscopy allows obtaining structural information on for example biomolecules by investigating the magnetic environment of paramagnetic centers on the atomic to nanoscale. This ... -
Development of 13C Liquid State Dynamic Nuclear Polarization at 9.4 Tesla
(2023-07-11)Throughout the last decades, nuclear magnetic resonance (NMR) spectroscopy in liquids contributed to the structural elucidation of molecules of many types and sizes. Continuous improvements of the hardware and pulse sequences ... -
Structural and Functional Investigations of Transmembrane Signaling Histidine Kinase Using NMR
(2022-11-04)Membrane proteins play a central role in biology as the gatekeepers of all cellular compartments. And transmembrane signaling through membrane bound kinases is a particularly important process for cellular adaptation to a ... -
<sup>17</sup>O hyperfine spectroscopy to investigate water binding to organic radicals
(2022-07-22)Hyperfine spectroscopy experiments detect nuclear spins around paramagnetic centers. They reveal magnetic interactions that contain valuable structural information on distance and orientation of the coupling partners. One ... -
From Paramagnetic Proteins to Field Alignment of Small Molecules
(2022-03-17)In this dissertation we show how to push the boundaries of structure elucidation using tensorial NMR parameters. Possible sources for these effects are paramagnetic centers or molecular alignment, and they contain valuable ... -
Development and Application of CP-ENDOR Spectroscopy on Protein Radicals
(2020-03-09)Electron-nuclear double resonance (ENDOR) spectroscopy is the method of choice for detecting magnetic nuclei in biomolecules which contain an unpaired electron spin. However, due to its low gyromagnetic ratio, the detection ... -
A twist in NMR relaxation experiments: Application to the study of protein motions
(2019-09-27)Understanding biological processes requires knowledge about the structure as well as dynamics of the involved molecules. Proteins are complex structures, which experience time dependent changes due to atomic motions. The ... -
Molecular insights into the Tau-actin interaction
(2018-05-04)Tau protein is classically considered as a neuronal microtubule-associated protein that stabilizes microtubules and supports the outgrowth of axons. The protein can modulate the transport of vesicles and organelles along ... -
Undersampled Radial STEAM MRI: Methodological Developments and Applications
(2018-03-09)The diffusion-weighted (DW) single-shot stimulated echo acquisition mode (STEAM) sequence offers DW MRI without susceptibility artifacts which severely hamper diagnostic applications when using conventional echo-planar ... -
Ribosome Processivity and Co-translational Protein Folding
(2017-04-21)Synthesis of polypeptide chains on the ribosome occurs at a non-uniform rate. mRNA sequences translated at a high rate are interspersed by segments that lead to translational pausing. The rate of translation elongation is ... -
Development of Advanced Acquisition and Reconstruction Techniques for Real-Time Perfusion MRI
(2017-01-09)This thesis concentrates on methodological developments in both acquisition and reconstruction techniques when applying concepts from real-time imaging to the field of dynamic contrast-enhanced magnetic resonance imaging. ... -
Fullerene-Nitroxide Derivatives as Potential Polarizers for Dynamic Nuclear Polarization (DNP) in Liquid State
(2016-09-12)Nuclear magnetic resonance spectroscopy and imaging (NMR/MRI) are widely applied methods for non-destructive analysis of biological systems, materials and medical applications. Dynamic nuclear polarization (DNP) is a method ... -
Structure-function relationships in wax producing enzymes
(2016-05-12)Wax esters (WEs) are esters of fatty acids and fatty alcohols. They can cover a broad range of physical properties, which makes them especially interesting for industrial applications, including additives in cosmetics and ... -
Regulation of Permeation in Aquaporins
(2016-02-19)Regulation of water permeation is an essential aspect of homeostasis in living organisms. Proteins of the ubiquitous aquaporin family act as trans-membrane tetrameric channels through which water may permeate under osmotic ... -
NMR Spectroscopy of the Tau-Microtubule Interaction
(2015-12-10)Tau is an intrinsically disordered, microtubule associated protein and is responsible for the promotion of microtubule (MT) formation and stabilization. The human Tau protein has six different isoforms, which are expressed ... -
Paramagnetic tools for the structural analysis of high molecular weight proteins
(2015-12-10)Paramagnetic effects provide important structural and dynamic information of biomolecules. However, the attachment of lanthanides through small chelating organic molecules to proteins (the most common way to obtain ... -
Dynamic interactions during ribosome targeting to the membrane
(2015-05-11)The signal recognition particle (SRP) and its receptor are the main components of the co-translational protein targeting pathway by which membrane proteins are targeted to the membrane. The co-translational targeting pathway ... -
Interaction of the SecYEG translocon with the SRP receptor and the ribosome
(2015-05-08)This work aimed at studying the interaction between SecYEG and FtsY and before and after the translating ribosome has been transferred to the SecYEG translocon. In this study we have used monomers of the SecYEG complex ... -
13C sparse labeling for solid-state NMR investigations of biomolecular systems
(2014-12-16)This thesis refers to 13C sparsely labeled strategies, including protein structure characterization on two different biomolecular systems, to obtain structural information via 13C-13C and 13C-15N correlations by solid-state ... -
Sensitivity Enhanced NMR
(2014-04-16)The topic of this thesis is the investigation of how sensitivity enhanced Nuclear Magnetic Resonance (NMR) spectra of biological systems could be obtained by dynamic nuclear polarization (DNP) under conditions close to ...