Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Commichau, Fabian Prof. Dr."
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Vitamin B6 metabolism and underground metabolic routes in the Gram-positive bacterium Bacillus subtilis
(2021-07-16)Genome-reduced bacteria give the opportunity to study essential gene functions but also give the starting point for biotechnological production pathways. The MiniBacillus project aims to produce a genome reduced Bacillus ... -
Signal transduction by the essential nucleotide second messenger cyclic di-AMP in Bacillus subtilis
(2021-01-15)Bacillus subtilis, as a soil inhabitant, has to adapt to rapidly changing osmotic conditions. The response to these osmotic changes represents one of the most critical issues in the lifecyle of bacteria, and the tight ... -
Clostridioides difficile: Analysis on Single Cell Motility and on Antibiotic Resistance
(2020-12-22)Clostridioides difficile, formerly in the genus Clostridium, is a Gram positive obligatory anaerobic spore forming bacterium. C. difficile is the leading nosocomial gastrointestinal pathogen in the western world. In ... -
A possible functional link between RNA degradation and transcription in Bacillus subtilis
(2020-09-24)Cellular levels of RNA depend on the rate of its synthesis and degradation. While synthesis is performed by RNA polymerase conserved in all domains of life, the enzymes responsible for RNA degradation are more unique ... -
A protein in search of a function: The c-di-AMP-binding protein DarA of Bacillus subtilis
(2019-07-26)Adaptation to changing environmental conditions is crucial for any organism to thrive in nature. Bacteria like the Gram-positive model organism Bacillus subtilis have evolved so-called second messengers to facilitate ... -
Identification of essential and virulence genes in Mycoplasma pneumoniae
(2019-04-16)The bacterial group of Firmicutes includes many pathogenic bacteria, as Mycoplasma pneumoniae. The Gram-positive, but cel wall-less bacterium is characterized by a minimal genome with only 694 genes. Elucidating the function ... -
MiniBacillus - the construction of a minimal organism
(2019-04-04)The MiniBacillus project is a minimal genome project. It attempts to reduce the genome of the model organism Bacillus subtilis in a top-down approach by deleting not necessary parts of the genome step by step. In this work, ...