Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Dickmanns, Achim Dr."
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A nuclear export sequence in Nup214 promotes its targeting to the nuclear pore complex
(2020-10-29)The nuclear pore complex (NPC) controls the communication between the nucleus and the cytoplasm in a selective manner via a hydrophobic barrier involving phenylalanine-glycine (FG) repeats. Interactions with components of ... -
Interplay of the COP9 signalosome deneddylase and the UspA deubiquitinase to coordinate fungal development and secondary metabolism
(2019-05-29)Protein half-life is controlled through the ubiquitin-proteasome system (UPS). Proteins are labeled with ubiquitin chains by E3 cullin RING ligases (CRLs) and then degraded by the 26S proteasome. The COP9 signalosome (CSN) ... -
Molecular Details of Membrane Deformation by ENTH Domains
(2018-03-20)During clathrin mediated endocytosis (CME) cargo molecules are transported across the plasma membrane from the outer cell surface into the cytosol. In this process, the plasma membrane undergoes massive local remodeling ... -
Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-binding Sites Involved in Nucleocytoplasmic Transport
(2015-09-09)Transport into and out of the nucleus occurs through nuclear pore complexes (NPCs) that are embedded in the nuclear envelope. NPCs are massive macromolecular complexes of around 125 kDa in vertebrates. Around 30 different ...