Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Doenecke, Detlef Prof. Dr."
Now showing items 1-14 of 14
-
Organelle dysfunction modulates cholesterol biosynthesis pathway
(2019-10-01)Mitochondria are known as the powerhouse of the cells. However, in recent years, it has become increasingly evident that mitochondria are involved in several signaling pathways. Lysosomes are membrane-bound organelles that ... -
Characterization of RNA-modifying enzymes and their roles in diseases
(2017-11-29)More than 150 types of chemical modifications have been identified in cellular RNAs (collectively called ‘’the epitranscriptome’’), and such modifications have emerged as important regulators of gene expression. Despite ... -
Systematic analysis of heterochromatin modification readout
(2017-06-14)Modifications of the building units of chromatin - the histone proteins and DNA - direct the functional readout of the genome and are part of the so called “epigenome” (Fischle et al., 2003b; Kouzarides, 2007). Several ... -
Structural Survey on Cohesin and Viomycin Inhibited 70S Ribosome by Single Particle Electron Microscopy
(2016-04-21)Life can be understood as the systematic collaborative action of several entities on molecular level reducing locally the entropy at the cost of the exterior environment. These entities are in great part macromolecular ... -
Atg26 is involved in selective autophagy of the major coat protein Gag of the S. cerevisiae virus L-A
(2016-01-22)Macroautophagy is a conserved catabolic pathway for the removal and recycling of cytosolic components, damaged or surplus organelles, protein aggregates or intracellular pathogens to maintain cellular homeostasis. It is ... -
Nuclear export of actin: A biochemical and structural perspective
(2015-08-18)Macromolecular exchange between the nucleus and the cytoplasm is mainly mediated by the RanGTP-dependent nuclear transport receptors (NTRs) of the Impβ family. NTRs are classified as importins and exportins according to ... -
Atg21 functions during autophagy as a scaffold for the E3 ubiquitin-‐like complex in Atg8 lipidation
(2015-01-23)Autophagy summarizes a family of intracellular lysosomal (vacuolar) degradative transport process. It is used for the removal and recycling of cytoplasm, protein aggregates and organelles to maintain cellular homeostasis. ... -
Exploration of cargo spectrum and NES patterns recognized by the exportin CRM1
(2014-10-15)The nuclear envelope (NE) subdivides eukaryotic cells into a nuclear and a cytoplasmic compartment, forcing material exchange between these two compartments to proceed through the nuclear pore complexes (NPCs). While ... -
Studying Protein Organization in Cellular Membranes by High-Resolution Microscopy
(2014-10-09)Most membrane proteins are found in clusters in the plasma membrane. For abundant proteins it is apparent that the clusters also tend to have patterned distributions, rather than being randomly scattered. To reveal the ... -
Functional characterization and application of 2',5'- branched RNA forming deoxyribozymes using lanthanides as cofactors
(2013-12-13)Deoxyribozymes or DNA catalysts are synthetic single stranded DNA molecules capable of catalysis for a wide range or reactions. Deoxyribozymes are discovered by in vitro selection and are mostly dependent on bivalent metal ... -
Structural and functional studies of the spliceosomal RNP remodeling enzyme Brr2
(2013-06-25)The spliceosome is a highly dynamic, multi-MDa eukaryotic RNA-protein (RNP) machinery that catalyzes precursor messenger RNA (pre-mRNA) splicing. Pre-mRNA splicing entails the excision of non-coding introns and the joining ... -
Myelin Membrane Growth and Organization in a Cellular Model System (EN)
(2011-01-19)This thesis addresses the two fundamental questions of myelin biogenesis: how the myelin membrane is extended and how it acquires its specific lateral organization. Myelin is a multilayered ... -
Mechanisms of the intracellular localization of the SUMO-activating enzyme Aos1/Uba2
(2010-06-16)Dynamic posttranslational modification with ubiquitin related proteins of the SUMO (small ubiquitin-related modifier) family is an important cellular mechanism to alter the activity, abundance ... -
USPL1, a novel SUMO isopeptidase
(2009-06-23)Small Ubiquitin-like Modifiers (SUMO) are 10 kDa proteins that are covalently attached to hundreds of intracellular proteins to regulate their function. In mammals, three members of the ...