Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Dosch, Roland Dr."
Now showing items 1-11 of 11
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Molecular Control of Germ Plasm Localization in Zebrafish
(2022-05-24)Germ plasm (GP) consists of a maternally inherited ribonucleo-protein (RNP) condensate, which controls in many animals the formation of germline. Only the cells which contain GP commit to germ cell destinies, whereas all ... -
Mechanism of Germ Cell Specification in Early Zebrafish Embryogenesis
(2021-07-19)Reproduction is an essential feature of life that ensures the perpetuation and survival in many multicellular organisms while passing the genetic information to the next generation. The zebrafish germline is specified ... -
Molecular Mechanisms of Germ Plasm Anchoring in the Early Zebrafish Embryo
(2020-08-14)Zebrafish germline is specified early during embryogenesis by inherited maternal RNAs and proteins called germ plasm. Only those cells containing germ plasm will become part of the germline, whereas other cells will ... -
Optimization and application of Trim-Away for studying a liquid-like spindle domain in mammalian oocytes
(2019-10-01)In this thesis, I reported a membraneless structure that permeated a major region of the female meiotic spindle and formed droplet-like protrusions around the spindle poles. Proteins within this previously unknown structure ... -
Mechanisms of synaptic plasticity mediated by Clathrin Adaptor-protein complexes 1 and 2 in mice
(2019-06-13)Clathrin adaptor protein complexes 1 and 2 (AP1 and AP2) have essential functions in synaptic vesicle (SV) recycling. In all cell types and tissues, AP1 mediates TGN/endosome protein sorting via clathrin-coated-vesicles ... -
Molecular investigation of mitochondrial inner membrane morphology
(2019-06-03)The mitochondrial inner membrane (MIM) is highly curved and displays a complex but extremely organised ultrastructure. It is subdivided into two morphologically, topologically, as well as functionally, distinct compartments. ... -
Novel export and import pathways in S. cerevisiae identified by an engineered SUMO system
(2018-09-07)Nuclear transport receptors (NTRs) mediate the translocation of cargos between the cytoplasm and the nucleus. NTRs are classified either as importins or exportins according to the directionality of the cargo transport. To ... -
Developmental Studies on Eye Types and Pedipalps in Parasteatoda tepidariorum
(2017-12-21)Arthropods are by far the most species rich phylum in the animal kingdom and their evolutionary success is at least in part rooted in their diverse morphology. Despite these morphological differences, arthropods share a ... -
The role of the mir-310s in Hedgehog Signaling regulation under dietary stress in the Drosophila ovary
(2016-02-03)Perturbations in nutrition and energy homeostasis can have deleterious effects on human health. Therefore, mechanisms controlling metabolic balance and initiating fast response to changing dietary conditions are essential. ... -
Pancreatic β-Cell Regeneration in TIF-IA Knockout Mice
(2014-09-30)As the sole source of insulin production in body, pancreatic β-cells play an essential role in glucose homeostasis. Diabetes mellitus is a chronic disease characterized by loss, reduction, and/or malfunction of β-cell mass. ... -
Role of cellular dynamics, adhesion and polarity in the context of primordial germ cell migration in Xenopus laevis embryos
(2014-02-11)Directional cell migration is an intensively studied process relevant for both normal development of an organism as well as for a number of pathological conditions such as chronic inflammation and cancer. Primordial germ ...