Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Fischle, Wolfgang Prof. Dr."
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Development of a ‘tool box’ for generating designer nucleosomes in high throughput fashion
(2017-11-23)Post-translational modifications of histones within nucleosomes regulate cell development, cell maintenance and cellular response to external factors. According to the histone code hypothesis, each biologic reaction is ... -
Systematic analysis of heterochromatin modification readout
(2017-06-14)Modifications of the building units of chromatin - the histone proteins and DNA - direct the functional readout of the genome and are part of the so called “epigenome” (Fischle et al., 2003b; Kouzarides, 2007). Several ... -
Mad2l2 as a safeguard for open chromatin in embryonic stem cells
(2016-08-08)Open chromatin is induced locally during the repair of DNA double-strand breaks when a cascade of protein recruitments and modifications is triggered. This "ATM cascade" includes components like the Mrn complex, ATM kinase, ... -
Role of Histone Methylation in Cognition and Effects of Different Durations of Environmental Enrichment on Learning and Memory
(2012-06-06)Part 1 Formation of stable long-term memories requires novel gene expression, and chromatin modifications have been shown to be involved in mediating the de novo gene expression which is necessary for memory formation. ... -
Biochemical and functional differences of chromatin assembled replication-coupled or independent in Xenopus laevis egg extracts
(2012-04-12)Two main chromatin assembly pathways ensure the proper transmission of chromatin organization and chromatin-based information throughout the cell cycle. A replication-dependent (RD) pathway that couples chromatin assembly to ... -
Functional analysis of mitochondrial sirtuins in C. elegans and mammalian cells
(2011-09-15)Silent information regulator 2 (SIR-2) proteins, also referred to as sirtuins, are highly conserved NAD+-dependent protein deacetylases that are emerging to be important energy sensors and ... -
Identification and characterization of ADNP as a novel heterochromatin component
(2011-03-29)In eukaryotic cells genetic information in the form of long linear DNA fibers is stored in the cell nucleus. Time and tissue specific gene expression patterns are manifested by the combination ... -
Characterization of LIN-61 methyl mark binding and its function in C. elegans vulva development
(2011-03-21)In eukaryotic cells the genome is packaged into chromatin, which is composed of core histones (H2A, H2B, H3, H4), non-histone proteins and DNA. Packaging of DNA into distinct chromatin ... -
Altered Histone 4 K12 Acetylation is Associated with Age Dependent Memory Impairment in Mice
(2010-10-29)The remarkable capability of the nervous system of animals to adapt their behavioral responses to an ever-changing environmental conditions is thought to rely on the plasticity of neuronal ...