Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Göpfert, Martin Prof. Dr."
Anzeige 1-20 von 32
-
Biophysical and molecular mechanisms of mean and variance adaptation in the Drosophila ear
(2023-05-16)Adaptation is an important mechanism found across sensory systems and species. This important ability of sensory systems expands our range of perception. Giving us the ability to perceive a quiet whisper as well as a loud ... -
Context, circuit and modulation of courtship signal selection in Drosophila
(2023-03-23)Communication is multi-modal -- when we interact, we speak, gesticulate, and touch. However, the neural computations and circuits that select and coordinate these communication signals are unclear. We address this issue ... -
Intercellular Coordination in Epithelial Morphogenesis
(2022-07-26)During the development of an embryo, tissue rearrangements are driven by the precisely coordinated activity of thousands of cells. How this high degree of organization is achieved and regulated is one of the most important ... -
Strategies for dynamic vision in the Drosophila peripheral visual system
(2022-04-21)Changes in luminance over space and time drive visual behaviors across species. Thus, sensitivity to luminance changes or contrast is fundamental to visual perception. Visual perception has to work in many different ... -
Network formation and reorganization of the olfactory system of Xenopus laevis
(2022-03-03)The olfactory system is a window to the chemical world, that permits each species to adapt to novel spaces and situations. Despite the various phylogenetic adaptations, this sensory system maintains similar functional and ... -
Structural determinants of voltage-dependent gating of Kv10.1
(2022-01-07)Voltage-gated ion channels sense voltage through the movement of the voltage sensor in response to change in membrane potential, hence influencing the channel pore. In this project, we seek a deeper understanding of ... -
Molecular physiology of sound encoding
(2021-10-26)Inner hair cells (IHC) are responsible for transforming mechanical sound-borne vibrations into electrical signals and conveying this information to the afferent spiral ganglion neurons (SGNs). Upon stimulation, the receptor ... -
Information processing in the olfactory system of different amphibian species
(2020-09-29)General similarities of the olfactory system from insects to mammals make it tempting to extrapolate from one species to the other. However, the olfactory system is remarkably adaptive and diversified among animal lineages ... -
Touch comes of Age - Maturational Plasticity in Somatosensory Mechanosensation
(2020-08-06)Somatosensory mechanosensation remains to be the least understood sensory system in vertebrates. It requires the activation of specialised neurons which innervate the skin and internal organs. A subset of these dorsal root ... -
Plasticity of Dopamine-Releasing Central Brain Neurons Underlying Adaptational Feeding-Related Behavior in Drosophila Melanogaster
(2020-05-07)All organisms have to adapt and adjust behaviors to changing environmental conditions. Foraging and feeding behaviors are one of the most adaptive behaviors when changes in nutrient sources occur. Neuronal and behavioral ... -
Characterization of distinct contrast- and luminance-sensitive pathways in the Drosophila visual system
(2020-02-03)Visual systems are capable of extracting relevant information from dynamically changing environments. This allows animals to locate objects, escape predators and collisions or estimate self-motion, among others. During the ... -
Role of mechanosensitive ion channels in coordinated epithelial cell dynamics in Drosophila
(2019-11-20)Epithelial cells are able to sense and mechanically respond to the forces and movements generated and transmitted through their neighbors. These forces are multicellular at the tissue level, and are transmitted via multimeric ... -
Thermosensory Transduction Mechanisms in Drosophila melanogaster
(2019-10-18)Ambient temperature has an profound effect in the physiology of all animals and accurate evaluation of both external and internal temperatures is therefore an essential factor for fitness and survival. To this end, animals ... -
Decoding the Epigenome of Neuronal Networks in Health and Disease
(2019-05-27)Alzheimer’s disease (AD) is the most prevalent form of dementia that has vast emotional and economic implications in our society. There is no cure for this neurodegenerative disorder as the pathological changes occur years ... -
In vivo approach to myelin turnover and oligodendrocyte-dependent axonal integrity
(2018-10-15)Deletion of the most abundant protein of CNS myelin, proteolipid protein (PLP) causes type 2 spastic paraplegia (SPG2) in humans, which is characterized by axonal degeneration. The assumption that the primary cause of SPG2 ... -
Linking senses: the genetics of Drosophila larval chordotonal organs
(2018-08-06)Sensory systems have evolved in all organisms to detect changes in the environment or their internal state. Even though they are essential for fitness and survival, their phylogenisis is still unclear. The protosensory ... -
Touching upon regulators of Piezo2 in mouse somatosensation
(2018-03-15)ABSTRACT Mechanosensation is an integral property of sensory systems like audition and somatosensation. The molecular determinants of mechanotransduction in mammals are only beginning to be understood. In 2010, Piezo2, a ... -
The role of attention and adaptation in shaping cortical representations and the perception of abrupt changes in the visual environment
(2017-11-22)The visual system receives a wealth of visual information about objects with changing features in time. Attention is a mechanism allowing us to prioritize the processing of relevant information at the expense of other ... -
Mechanical Properties of the lch5 Organ in the Drosophila Larva
(2017-09-08)I begin with a brief account of the topic of mechanosensation, followed by an outline of how the project evolved. The experimental techniques used and their rationale are described. The section ends with a short description ... -
Analyzing receptor responses in the Drosophila Johnston's organ with two-photon microscopy
(2017-07-31)Hearing organs rely on force-gated ion channels to convert the mechanical energy imposed by sound into receptor potentials usable by the nervous system. So far, little is known about the identity and working mechanisms of ...