Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Görlich, Dirk Prof. Dr."
Now showing items 1-11 of 11
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Mechanistic and structural characterization of human L-asparaginases
(2024-04-04)L-asparaginases are therapeutic proteins against acute lymphoblastic leukaemia (ALL), especially in children. As lymphoblastic cells depend on L-asparagine in the blood serum, its depletion by L-asparaginases leads to ... -
Mechanism of non-canonical ubiquitination by ubiquitin conjugating enzyme Ubc6
(2023-10-18)Protein quality control by ubiquitination occurs due to the sequential action of three enzyme classes: ubiquitin-activating (E1), ubiquitin-conjugating (E2) and ubiquitin-ligases (E3). Conventionally, ubiquitin (Ub) ... -
Colloidal Probe Force Spectroscopy
(2021-10-26)This thesis demonstrates how colloidal probe force spectroscopy, in connection with reconstituted biological model systems and theoretical models, allows us to investigate and understand the behavior of a wide variety ... -
Characterization of RNA-modifying enzymes and their roles in diseases
(2017-11-29)More than 150 types of chemical modifications have been identified in cellular RNAs (collectively called ‘’the epitranscriptome’’), and such modifications have emerged as important regulators of gene expression. Despite ... -
In vitro investigation of trans SNARE complexes arrested between artificial membranes
(2015-09-23)The key components of the machinery that catalyzes membrane fusion include membrane-associated small proteins that are termed as soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). Calcium-triggered ... -
MS-based quantitative analysis of the CRM1 export pathway and spatial proteomics of the Xenopus laevis oocyte
(2015-09-22)Nuclear export is a vital cellular process, which supplies the cytoplasm with essential biological macromolecules, such as matured tRNAs and ribosomal subunits. This process is carried out by a set of proteins called ... -
Nuclear export of actin: A biochemical and structural perspective
(2015-08-18)Macromolecular exchange between the nucleus and the cytoplasm is mainly mediated by the RanGTP-dependent nuclear transport receptors (NTRs) of the Impβ family. NTRs are classified as importins and exportins according to ... -
Dynamics and mechanics of adherent cells in the context of environmental cues
(2015-03-25)Cellular behavior is influenced by many biochemical but also physical factors in the direct cellular environment. Thereby, cells not only react to external cues, the interaction between cells and their environment is also ... -
Systematic analysis of the interactome of modified chromatin
(2013-09-13)Regulation of chromatin composition and structure is crucial for maintaining genome integrity and execution of the wide array of functions related to gene regulation and downstream cell signaling. Chemical modifications ... -
Molecular mechanisms of lipid-rich myelin membrane sheet formation
(2013-02-13)Myelin is a membrane of vital importance. In the vertebrate nervous system, it promotes rapid conduction of nerve impulses via insulating the axons. To act as an insulator, myelin needs to assemble into a stable, lipid-rich ... -
Identification of nuclear export signals and structural analysis of transport complexes.
(2013-01-09)The nucleus is a vital sub cellular compartment and it stores the genome. Transport across the nuclear envelope occurs through Nuclear Pore Complexes (NPC) and cargo traffic across the NPCs is a highly specific and ...