Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Günesdogan, Ufuk Dr."
Now showing items 1-9 of 9
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Mechanisms of chromosome segregation in mammalian oocytes
(2024-12-10)Errors in chromosome segregation in human females often result in eggs with the wrong number of chromosomes, a condition known as aneuploidy. The rate of aneuploidy increases dramatically in women with age, particularly ... -
Reorganization of the Senescent Genome via Spatial CTCF Clustering
(2023-07-13)Cellular senescence is now understood to be a major hallmark of the aging process. Senescence can be induced by many stress factors, including telomere shortening, DNA damage and tumor- suppressor genes activation and ... -
Dependency of 3D chromatin folding on RNA polymerase II at different cell cycle stages
(2023-07-13)In human cells, the genetic information is organised in a multilayer fashion. During the cell cycle, chromatin undergoes dramatic structural changes. For proper inheritance, chromatin is compacted to chromosomes in ... -
Coordination of the cell cycle and the cytoskeleton during oocyte meiosis
(2023-06-29)Meiosis serves to reduce ploidy, to half the genetic content of germ cells before they unite again at fertilization. This is achieved by two subsequent divisions called meiosis I and II without an intermittent S-phase. In ... -
Chromatin reorganization, signaling responses and non-coding RNA regulators in homeostasis and senescence
(2022-04-21)In mammalian cells, a relatively limited fraction of genetic information is utilized in a variety of ways to give rise to distinct cellular phenotypes. Thus, the genotype essentially acts as input for multilayered regulatory ... -
Dissecting the molecular mechanism and spatiotemporal dynamics controlling senescence entry
(2021-01-21)Senescence represents a programmed cell cycle arrest against aberrant proliferation and tumour development due to accumulated genotoxic or metabolic stress. The tumour-suppressive properties of senescence attracted the ... -
Molecular Mechanisms of Germ Plasm Anchoring in the Early Zebrafish Embryo
(2020-08-14)Zebrafish germline is specified early during embryogenesis by inherited maternal RNAs and proteins called germ plasm. Only those cells containing germ plasm will become part of the germline, whereas other cells will ... -
Mechanisms of pronuclear migration in mammalian zygotes
(2019-08-30)In sexually reproducing species, life begins with the fusion of egg and sperm to form the one-cell embryo, called the zygote. Maternal and paternal DNA form the female and male pronuclei, and must migrate to each other to ... -
Role of Distal Regulatory Elements in Cancer Progression and Therapy
(2019-01-11)Enhancer elements comprise of regions of DNA that are distal to gene promoters with a characteristic capacity to affect and regulate gene transcription. Enhancers are enriched in a highly context-specific manner allowing ...