Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Gollisch, Tim Prof. Dr."
Now showing items 1-20 of 21
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Functions and Origins of Nonlinear Processing in the Retina
(2024-11-29)Millions of people worldwide suffer from terminal blindness, but state-of-the-art vision restoration devices can only produce a sensation fundamentally different from natural seeing. We lack the sufficient understanding ... -
Development of an in-silico framework for the engineering and evaluation of future optogenetic cochlear implants
(2024-09-27)Hearing loss is a prevalent global challenge with profound cognitive, psychological, social, and economic implications. Traditional cochlear implants (CIs)—neuroprosthetic devices to partially restore hearing—stimulate the ... -
Developing tools for translational In-vivo cochlear optical stimulation
(2024-07-02)Utilizing optogenetic stimulation to target type I spiral ganglion neurons (SGNs) could promise an alternative to the currently employed electrical stimulation by current cochlear implants (CIs). Given light's spatial ... -
Ultrastructural study of synaptic vesicle dynamics in murine inner hair cell ribbon synapses under sustained stimulation
(2023-07-11)Transmission of auditory information relies in the correct functioning of inner hair cell (IHC) rib-bon synapses, which mediate synaptic vesicle release in an indefatigable manner. The name-giving synaptic ribbon and the ... -
How nonlinear processing shapes natural stimulus encoding in the retina
(2022-05-31)Understanding natural vision is one of the fundamental goals of sensory neuroscience. The only part of the visual system that may currently be amenable to such a complete understanding is the vertebrate retina, where there ... -
Strategies for dynamic vision in the Drosophila peripheral visual system
(2022-04-21)Changes in luminance over space and time drive visual behaviors across species. Thus, sensitivity to luminance changes or contrast is fundamental to visual perception. Visual perception has to work in many different ... -
Intracortical mechanisms compensating weakened thalamic input in the hyperexcitable somatosensory cortex of reeler mutant mice.
(2022-01-21)In the severely disorganized reeler primary somatosensory cortex, thalamocortical axons manage to target layer 4-fated neurons. Although the reeler somatosensory cortex maintains proper activation in response to sensory ... -
Neural representation of complex motion in the primate cortex
(2021-11-04)This dissertation is concerned with how information about the environment is represented by neural activity in the primate brain. More specifically, it contains several studies that explore the representation of visual ... -
Auditory associative learning and its neural correlates in the auditory midbrain
(2021-01-08)Interpreting the meaning of environmental stimuli to generate optimal behavioral responses is essential for survival. Simply sensing a sound, without accessing prior knowledge in the brain, will not benefit behavior. How ... -
Receptive field organization of motion computation in the fly: a study of cell types and their variability
(2020-12-02)It is believed that knowing all cell types making up a brain will lead to its understanding. Consequently, current efforts focus on classifying cell types according to their anatomical, genetic and physiological properties. ... -
Neuronal control of sleep in Caenorhabditis elegans
(2020-11-03)Sleep is crucial for all organisms with a nervous system. Amongst other functions, it is required for energy allocation, higher brain functions and the control of physiological processes. Sleep-active neurons have ... -
Towards Optical Cochlear Implants: Behavioral and Physiological Responses to Optogenetic Activation of the Auditory Nerve
(2019-11-15)Cochlear implants (CIs) constitute the interface between the sound-deprived brain of patients suffering from sensorineural hearing loss and the auditory scene surrounding them. By electrically stimulating the auditory nerve ... -
Thermosensory Transduction Mechanisms in Drosophila melanogaster
(2019-10-18)Ambient temperature has an profound effect in the physiology of all animals and accurate evaluation of both external and internal temperatures is therefore an essential factor for fitness and survival. To this end, animals ... -
Optogenetic stimulation of the cochlea
(2019-07-15)Optogenetic stimulation of the auditory nerve is a promising alternative to restore hearing. Since light can be focused on the target tissue, the optical cochlear implant (oCI) might support a major improvement in frequency ... -
Ultrastructural Characterization of The Output of VIP Expressing Interneurons in Mouse Barrel Cortex
(2017-11-15)Based on this preliminary result, a quantitative immunoelectron microscopy study was adopted to comprehensively characterize the output of VIP interneurons across the whole laminae of mouse barrel cortex. Using VIPcre/YFP ... -
The role of postsynaptic density (PSD) proteins PSD-95 and PSD-93 for mouse visual cortical plasticity and vision
(2017-09-25)During neurodevelopment in the brain, several changes including structural, molecular and functional changes take place in order to promote its maturation. These changes occur at multiple levels, with modifications in ... -
Weakly Selective Training induces Specialization within Populations of Sensory Neurons
(2016-12-16)Many neurons in sensory pathways respond selectively to a narrow class of stimuli such as faces or specific communication calls. At the same time neural processing is robust to a large degree of natural variablity ... -
Motion encoding in the salamander retina
(2016-10-20)The detection and correct interpretation of motion in visual scenes is important in everyday tasks, e.g., for avoiding cars when crossing the street or for assessing the optic flow, induced by self-motion, when navigating ... -
Order under the guise of chaos: functional neuroanatomy of the somatosensory "barrel" cortex of the reeler mutant mouse
(2016-05-13)Rodents possess an array of facial whiskers on either side of their snout, which they use to collect tactile information about their surroundings. In layer IV of the somatosensory cortex, individual whiskers are represented ... -
Physiological Classification of Retinal Ganglion Cells in the Salamander Retina
(2016-04-13)The retina is a complex neural network, responsible for breaking down the visual scene into its distinctive features such as local contrast, motion and color. The retinal ganglion cells form the output layer of this ...