Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Groß, Uwe Prof. Dr."
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Phenotypic and Functional Characterization of Natural Killer Cell Receptors in Human and Rhesus macaque
(2024-02-05)Activating killer immunoglobulin-like receptors (KIRs) cannot transmit signals directly but through signaling motifs. Since human activating KIRs lack signaling molecules, their transmembrane lysine residue pairs with ... -
Cell and Receptor Tropism of γ2-Herpesviruses
(2021-02-25)Kaposi’s sarcoma-associated herpesvirus (KSHV), the only rhadino- or γ2-herpesvirus of humans, is associated with Kaposi’s sarcoma (KS) and two B cell proliferative malignancies, primary effusion lymphoma (PEL) and a ... -
Characterization of host cell factors used by emerging coronaviruses for entry into target cells
(2020-07-24)Human coronaviruses (HCoV) mainly cause common cold-like symptoms. However, in the last two decades the emerging coronaviruses the severe acute respiratory syndrome coronavirus (SARS-CoV) (in 2002), Middle East respiratory ... -
Interactions of the Ebola virus glycoprotein with host cell factors during viral entry and release
(2019-03-28)Ebola virus disease (EVD) is a severe disease that affects humans and non-human primates. The recent EVD epidemic in West Africa shows that EVD poses a severe threat to human health. EVD is caused by Ebola virus (EBOV) and ... -
Investigation of prokaryotic immune defense system with quantitative and structural mass spectrometry
(2016-02-26)Bacteria and archaea have evolved an adaptive and heritable immune defense system comprising a CRISPR (clustered regularly interspaced short palindromic repeats) locus and Cas (CRISPR-associated) proteins that targets ... -
AfuSomA transcriptional network in human pathogen Aspergillus fumigatus
(2015-05-19)Fungal development is regulated by environmental stimuli via various signaling pathways. For instance, the cyclic AMP dependent protein kinase A (PKA) cascade is controlling development or pathogenesis in fungi as filamentous ... -
Modulation of allergic airway inflammation by glucocorticoids
(2014-03-06)A crucial step in the development of improved drugs for asthma therapy is a thorough understanding of the mechanisms, which are important for effective treatment, and the identification of target cells in asthma pathogenesis. ...