Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Großhans, Jörg Prof. Dr."
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Mechanics and Motility of Epithelial Cells: From Single Cell Behavior to Collective Migration
(2023-01-13)Mechanical behavior of cells plays a crucial role in a plethora of biological processes. Despite its importance, this aspect of life science has only more recently gained increasing interest. Yet, without mechanical force ... -
Intercellular Coordination in Epithelial Morphogenesis
(2022-07-26)During the development of an embryo, tissue rearrangements are driven by the precisely coordinated activity of thousands of cells. How this high degree of organization is achieved and regulated is one of the most important ... -
Nuclear mRNA quality control factors Gbp2 and Hrb1 take part in cytoplasmic mRNA surveillance through nonsense-mediated decay
(2022-01-27)Yeast SR-like proteins Gbp2 and Hrb1 shuttle between the nucleus and the cytoplasm, and serve as quality control factors for pre-mRNA splicing. They are loaded onto the RNA co-transcriptionally, and upon correct splicing, ... -
Regulation Of Spindle Orientation By A Mitotic Actin Pathway In Chromosomally Unstable Cancer Cells
(2020-11-18)Aneuploidy is a hallmark of human cancer and is observed in 90 % of solid tumors. The perpetual gain or loss of whole chromosomes, defined as chromosomal instability (CIN), represent one mechanism causing aneuploidy. CIN ... -
Reverse-time inference of biological dynamics
(2020-10-27)In this work I derive a mathematical theory that allows to infer directional biological dynamics in reverse time starting from their target state. I use this approach to infer an effective model of cell junction shrinkage ... -
Investigating the Re-initiation of Segmentation with Temporally Restricted RNAi in Tribolium castaneum
(2020-10-01)Much of the success of arthropods is attributed to their body’s segmentation. Segmentation provides various opportunities for nature to evolve new structures without greatly impacting overall fitness of the animal. Most ... -
Collective Mechanical Behavior of Epithelial Cells - The Impact of Micro-Wounding
(2019-06-24)For epithelia, which are lining organs or blood vessels, the mechanical integrity of a whole cell sheet is indispensable. The question arises, how neighboring cells mechanically work together to build a functioning cell ... -
Roles of miR-137 in Muscular Dystrophy and Muscular Dystrophy-Related Phenotypes in Drosophila melanogaster
(2019-05-07)Muscular dystrophies (MDs) are a group of diseases that cause muscular and neurological disorders in human patients. They are associated with a multi-component complex called the Dystrophin Glycoprotein Complex (DGC). The ... -
Head versus tail: germ cell-less initiates axis formation via homeobrain and zen1 in a beetle
(2018-08-27)The iBeetle screen project: Christiane Nüsslein-Volhard and Eric Wieschaus performed the first saturated forward genetic screen using random mutagenesis to identify genes important for embryonic development in Drosophila ... -
Iron Homeostasis in Neuron-Glia Interaction
(2018-03-15)One major function of glial cells is to support neurons and create an environment that allows fast signal propagation. However, when neurons are ensheathed, they also get isolated from the extracellular environment and can ... -
Role of the nuclear lamina for stem cell mediated homeostasis
(2016-11-22)The nuclear lamina is a protein meshwork at the inner side of the inner nuclear membrane and connects to essential cellular structures like chromatin, the nuclear pore complex and the cytoskeleton. The nuclear lamina is ... -
Role of Serine hydroxymethyltransferase in cell cycle control and early Drosophila development
(2016-10-10)The early development of Drosophila melanogaster occurs in a syncytium, where nuclei undergo mitotic divisions without accompanying cytokinesis. Early cleavage cycles are very short and consist only of S and M phases. In ... -
Intracellular micromechanics of the syncytial Drosophila embryo
(2015-09-28)A developing embryo is a striking and fascinating example of self-organization and collective behavior of biological matter. In the presented work, I investigated the cytoplasmic interior of Drosophila melanogaster ... -
Nuclear export of actin: A biochemical and structural perspective
(2015-08-18)Macromolecular exchange between the nucleus and the cytoplasm is mainly mediated by the RanGTP-dependent nuclear transport receptors (NTRs) of the Impβ family. NTRs are classified as importins and exportins according to ... -
Ecdysone signaling and miRNA let-7 cooperate in regulating the differentiation of the germline stem cell progeny
(2015-05-06)Adult stem cells are found in most adult tissues where they are responsible for replacing cells that are lost due to turnover or injury. They have the unique ability to give rise to differentiated progeny, while at the ...