Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Höbartner, Claudia Prof. Dr."
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Characterization of RNA-modifying enzymes and their roles in diseases
(2017-11-29)More than 150 types of chemical modifications have been identified in cellular RNAs (collectively called ‘’the epitranscriptome’’), and such modifications have emerged as important regulators of gene expression. Despite ... -
Development of new methods in fluorescence microscopy
(2015-12-02)In recent years, advancements in single-molecule imaging techniques have enabled scientists to study in great detail the cells and relevant physiological processes, including neurons and the communication between them. ... -
Interactions and functions of RNA-binding proteins
(2018-04-13)Alongside several well-known modifications in DNA and proteins, more than 100 different types of chemical modification are also found in cellular RNAs. RNA modifications can influence the secondary structure and interactions ... -
Paramagnetic tools for the structural analysis of high molecular weight proteins
(2015-12-10)Paramagnetic effects provide important structural and dynamic information of biomolecules. However, the attachment of lanthanides through small chelating organic molecules to proteins (the most common way to obtain ... -
Structural investigation of functional nucleic acids
(2021-06-30)DNA enzymes, also known as deoxyribozymes, are synthetic single-stranded DNA molecules able to catalyze chemical reactions. There are two main reasons for studying deoxyribozymes: their practical value in various applications, ... -
Structure-function analysis of human nucleotide excision DNA repair
(2021-04-09)An average human cell accumulates tens of thousands of DNA lesions per day. Therefore, DNA repair pathways are set up to continuously proofread the DNA and correct DNA lesions, thus ensuring accurate expression and ...