Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Hörner, Michael Prof. Dr."
Now showing items 1-7 of 7
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In vivo approach to myelin turnover and oligodendrocyte-dependent axonal integrity
(2018-10-15)Deletion of the most abundant protein of CNS myelin, proteolipid protein (PLP) causes type 2 spastic paraplegia (SPG2) in humans, which is characterized by axonal degeneration. The assumption that the primary cause of SPG2 ... -
Activity-based automatic ROI generation (AARG) analysis of dendritic spine calcium transients reveals distance-dependent activity of voltage-gated calcium channels
(2018-03-20)Imaging synaptic activity in the form of calcium transients occurring in dendritic spines is advancing our understanding of nerve cell function beyond what can be achieved using electrophysiological methods alone. I have ... -
Roles of PSD-93 and environmental enrichment in cortical synapses
(2015-11-10)During neurodevelopment several structural, molecular and functional changes take place in the brain to promote its maturation. These changes occur at multiple levels, including changes in protein expression, in the strength ... -
A novel membrane-binding probe for the morphological and molecular characterization of synaptic vesicle recycling pathways
(2015-05-12)An important anatomical feature of neuronal synapses is the presynaptic bouton, a structure that isolates synaptic vesicle recycling from constitutive membrane trafficking pathways. However, in some neurotransmitter-releasing ... -
Combining Transcranial Electrical Stimulation With Magnetic Resonance Imaging In Behavioural Measurements In Health And Disease
(2014-04-09)The ability of the brain to rearrange its circuitry and adapt its functioning is termed neuroplasticity and underlies early brain development and complex brain functions, such as learning and memory formation. Furthermore, ... -
Epigenomic Imaging of Neuropsychiatric Diseases
(2013-12-13)Schizophrenia is a severe neuropsychiatric disorder with high phenotypic complexity and multifactorial inheritance. Cognitive dysfunctions have been identified as the core feature of the disease and they are resistant to ... -
Maturation of ribbon synapses in hair cells is driven by thyroid hormone
(2007-06-07)Ribbon synapses of inner hair cells (IHCs) undergo developmental maturation until after the onset of hearing. Here, we studied whether IHC synaptogenesis is regulated by thyroid hormone ...