Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Hahn, Heidi Prof. Dr."
Now showing items 1-17 of 17
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Characterisation of primate primordial germ cells in vitro
(2024-06-17)Primordial germ cells (PGCs) are embryonic precursors of sperm and eggs, responsible for passing on genetic and epigenetic information throughout the generations. For certain mammalian species, the development of PGCs can ... -
Role of antibodies in autoimmunity of the central nervous system
(2020-07-09)Although T cells are the main players in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), the role of B cells and their soluble effector molecules (antibodies) is being progressively ... -
Role of Distal Regulatory Elements in Cancer Progression and Therapy
(2019-01-11)Enhancer elements comprise of regions of DNA that are distal to gene promoters with a characteristic capacity to affect and regulate gene transcription. Enhancers are enriched in a highly context-specific manner allowing ... -
The Cellular Function of USP22 and its Role in Tissue Maintenance and Tumor Formation
(2018-02-12)Colorectal cancer (CRC) is the most frequent malignancy of the gastrointestinal tract and therefore reflects a global health issue. Despite improved detection and treatment options the high mortality and morbidity rates ... -
The role of LEF1 and WNT signaling in growth and differentiation of rhabdomyosarcoma
(2017-02-16)Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children and shows characteristics of skeletal muscle differentiation. RMS occur in two main histological subtypes in children: alveolar RMS (ARMS) ... -
The Role of RNF40 mediated H2B monoubiquitination in transcription
(2017-02-13)Active gene transcription is tightly correlated with the occupancy of histone H2B monoubiquitination (H2Bub1) in the transcribed region. Therefore, it is has been commonly assumed that H2Bub1 is an exclusively positively ... -
The Role of CHD1 during Mesenchymal Stem Cell Differentiation
(2017-01-23)Nucleosome remodeling, histone modifications and exchange of histone variants are interconnected mechanisms involved in regulation of gene transcription. Nucleosomes can act as strong barriers and are remodeled during ... -
Controlled levels of canonical Wnt signaling are required for neural crest migration
(2016-01-22)Canonical Wnt signaling has been shown to orchestrate the development of the neural crest (NC), a transient population of multipotent, migratory cells that generate a vast array of cell types. Canonical Wnt signaling is ... -
Wif1 Inhibits the Growth of Basal Cell Carcinoma
(2015-12-22)Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin cancers and is the most commonly diagnosed cancer in fair-skinned individuals. In the majority of BCC the tumor suppressor gene patched1 (PTCH) is ... -
Combining gemcitabine with checkpoint kinase inhibitors to sensitize pancreatic tumors
(2015-04-15)Pancreatic tumor is one of the leading causes of cancer-related deaths in the world. Currently, the nucleoside analogue gemcitabine is the leading therapeutic drug for the treatment of pancreatic tumors. However, due to ... -
Cooperation of p300 and iASPP in apoptosis and tumour suppression
(2014-11-04)Mutation or functional inactivation of tumour suppressors represents a key event in the transformation of cells and contributes to the development of cancer. P300 and CBP constitute two histone acetyltransferases with ... -
Drug Metabolism Determines Resistance of Colorectal Cancer to Resorcinol-Based HSP90 Inhibitors
(2014-11-04)Tumor cells are characterized by intrinsic proteotoxic stress and the accumulation of mutated proteins. Therefore, malignant cells depend on the activity of heat shock protein 90 (HSP90) much more than normal cells to ... -
Modulation of allergic airway inflammation by glucocorticoids
(2014-03-06)A crucial step in the development of improved drugs for asthma therapy is a thorough understanding of the mechanisms, which are important for effective treatment, and the identification of target cells in asthma pathogenesis. ... -
The Role of the Hedgehog Receptor Patched in LysM+ Cells in Mice
(2013-12-04)Cancer development is frequently linked to signaling pathways that are required for normal embryonic patterning. One of the pathways important in patterning and growth of the embryo is the Hedgehog (Hh) signaling cascade. ... -
The role of H2B monoubiquitination in cellular differentiation
(2013-06-24)Histones, subjected to post-translational modifications, are important regulators of the cellular processes. One of these modifications is monoubiquitination of histone H2B (H2Bub1). H2Bub1 is associated with the actively ... -
Role of the Hedgehog receptor Patched1 in the development and function of T lymphocytes
(2013-06-18)The hedgehog signalling pathway is a highly conserved key regulator of animal development and required for homeostasis of adult tissues both in invertebrates and vertebrates. In addition, a large number of studies have ... -
Role of Rho GTPases During Primordial Germ Cell Migration in Zebrafish
(2008-11-26)Cell migration is an essential biological process during development, adult homeostasis, and disease. Actin cytoskeleton plays crucial role in generating forces required for cell migration. ...