Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Hillen, Hauke Prof. Dr."
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Characterization of TMEM209, a transmembrane protein of the nuclear envelope
(2025-04-29)The nuclear envelope (NE) comprises the outer nuclear membrane (ONM) and inner nuclear membrane (INM), which are connected at the level of nuclear pore complexes (NPCs). A variety of transmembrane proteins is found at the ... -
Structural and biochemical studies on co-transcriptional endonuclease reactions
(2025-03-25)Influenza, an acute respiratory disease, causes 290,000 to 650,000 human deaths annually (Iuliano et al., 2018; WHO, 2023). During an influenza infection, the virus ensures proper handling of viral mRNA, including nuclear ... -
Rate-limiting steps of autophagy initiation
(2024-12-23)Autophagy research has progressed tremendously since the identification of ‘ATG’ genes and proteins responsible for maintaining the process. A dissection of general functions of all proteins involved was possible. However, ... -
Structural and biochemical studies on chromatin-protein complexes in transcription initiation
(2024-04-02)Gene expression is an essential process in the cell for the development and homeostasis of any organism. The eukaryotic genome is tightly packed with nucleosomes, the basic unit of chromatin, which protects DNA integrity. ... -
Release of a Natural mRNA During Recycling of the Prokaryotic Ribosome
(2023-06-20)Ribosome recycling is the last step of the bacterial translation cycle. The release of the peptide leaves a 70S ribosome with a deacylated tRNA in the P site and the stop codon of the mRNA in the A site. The combined action ... -
Nuclear transport of the nitric oxide synthase interacting protein (NOSIP)
(2023-05-23)Proteins that need to actively enter the nucleus are thought to be transported by a specific nuclear transport receptor (NTR), depending on the type of the nuclear localization signal (NLS). Some cargoes are reported to ... -
Co-translational processing and membrane insertion of proteins in bacteria
(2022-11-04)Protein biogenesis entails the synthesis of polypeptides on the ribosome, their co- and post-translational maturation, folding, and, in the case of membrane proteins, insertion into the lipid bilayer. Bacterial proteins ...