Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Hoyer-Fender, Sigrid Prof. Dr."
Now showing items 1-11 of 11
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Manipulating co-regulators of RUNX2 and SOX9 to enhance the chondrogenic potential of chondrogenic progenitor cells in osteoarthritis
(2020-12-11)Osteoarthritis (OA) is a degenerative disease of the joint leading to the degradation of the articular cartilage. Current therapies cannot halt or reverse the disease, leading to a severe impact on life quality accompanied ... -
The role of Hedgehog signalling in pituitary homeostasis in vitro and in vivo
(2020-11-03)The pivotal role of the Hedgehog (Hh) signalling pathway during embryonal development of the pituitary gland is well established. However, the knowledge about its function in the adult pituitary is still sparse. Our group ... -
The Evolutionary Establishment of Apomixis in Hybrids of the Ranunculus auricomus Complex: Developmental and Cytogenetic Studies
(2020-06-16)In plant evolution, polyploidization and hybridization are important forces that both effectively contribute to developmental alterations. Asexual seed formation, known as apomixis, is mainly found in polyploid and/ or ... -
Spatio-temporal dynamics in the anchoring of cilia
(2019-10-02)The ventricular system of the mammalian brain consists of the two lateral, a third, and a fourth ventricle that interconnect and are filled with circulating cerebrospinal fluid (CSF) (1). CSF streams along the ventricular ... -
Mechanisms of pronuclear migration in mammalian zygotes
(2019-08-30)In sexually reproducing species, life begins with the fusion of egg and sperm to form the one-cell embryo, called the zygote. Maternal and paternal DNA form the female and male pronuclei, and must migrate to each other to ... -
Analysis of the Wnt receptors Ror, Otk and Otk2 during nervous system development in Drosophila melanogaster
(2016-01-20)Wnt signaling regulates many developmental and adult physiological processes. This is achieved through the activation of several distinct Wnt pathways. The outcome is determined by a specific combination of a Wnt ligand ... -
CHARGE syndrome: candidate genes and pathogenesis
(2015-09-25)CHARGE syndrome is a complex malformation syndrome affecting several organ systems like the central nervous system, ear, eye and heart. Heterozygous loss of function mutations in CHD7, a conserved chromatin remodelling ... -
Transcription factor Pax6 controls structure and function of the centrosome in cortical progenitors
(2013-07-15)The mammalian neocortex is a highly complex structure containing more than 100 billions neurons and ten times more glia cells that are generated during development by progenitor cells located at the apical surface of the ... -
Characterization of LIN-61 methyl mark binding and its function in C. elegans vulva development
(2011-03-21)In eukaryotic cells the genome is packaged into chromatin, which is composed of core histones (H2A, H2B, H3, H4), non-histone proteins and DNA. Packaging of DNA into distinct chromatin ... -
Functional Analysis of Heat Shock Protein HSPA4
(2010-11-17)The aims of this study were to determine the underlying causes of male infertility, growth retardation and cardiac hypertrophy in Hspa4-/- mice. In order to identify the spermatogenic ... -
On the putative role of Pelota in stem cell differentiation
(2010-04-20)In this work we analyzed the role of pelota in the conditional knockout mouse model. We shed light on its function during development and report the defects resulting from Pelota depletion. ...